摘要
目的:探讨年轻妇女宫颈癌的临床特征、术后复发及预后相关因素。方法:选择≤35岁行宫颈癌根治术的90例患者为研究组,同时随机选取同期>35岁行宫颈癌根治术的90例患者为对照组,比较两组的临床特征及研究组中复发(46例)与未复发(44例)患者的临床病理资料,并对影响预后(5年生存率)的相关因素进行单因素和多因素分析。结果:1研究组仅阴道不规则流血比例(15.56%)高于对照组(7.78%),差异有统计学意义(P<0.05),两组接触性阴道流血、白带增多、腰痛或者腹痛、无症状及病程比较,差异均无统计学意义(P>0.05)。2研究组复发与未复发患者的临床病理因素比较,初治时肿瘤大小、临床分期、组织学分级、宫颈浸润深度及盆腔淋巴结转移差异有统计学意义(P<0.05)。3单因素分析表明,临床分期、宫颈浸润深度和盆腔淋巴结转移是影响研究组和对照组5年生存率的共同因素。多因素分析表明,研究组患者中宫颈浸润深度、临床分期及盆腔淋巴结转移是影响预后的独立危险因素。结论:年轻宫颈癌患者的临床特征不典型。系统治疗后应对患者术后复发的高危因素进行排查和随访。对于影响预后的独立危险因素,应建立系统的防控体系,提高患者无瘤生存的时间和质量。
Objective： To investigate the clinical characteristics,postoperative recurrence and prognosis related factors of young women with cervical cancer. Methods： 90 patients whose age ≤35 treated with radical operation of cervical cancer were chosen as research group,90 patients whose age35 treated with radical operation of cervical cancer were chosen as control group. The clinical characteristics and the pathology data of recurrent cases（ 46cases） and non-recurrent cases（ 44 cases） in research group were analyzed,and the risk factors of prognosis were analyzed by single and multiple-factor analysis. Results： 1The rate of irregular vaginal bleeding of research group（ 15. 56%） was higher than control group（ 7. 78%）（ P0. 05）. No significant difference was found in contact bleeding,leukorrhagia,lower back pain or stomachache,asymptom and disease course between two groups（ P0. 05）. 2The single factor analysis showed that clinical stage,depth of cervical invasion and metastasis of pelvic lymph nodes were related to the 5-year survival rate. 3Multiple factor analysis showed that the clinical staging,depth of tumor invasion and lymph node metastasis were independent risk factors of prognosis. Conclusions： The clinical characteristics of young women with cervical cancer is atypical. We should pay more attention to the recurrent risk factors. Tumor size,clinical stage,histological grade,depth of cervical invasion and pelvic lymph node metastasis were related to recurrence. The depth of tumor invasion and pelvic lymph node metastasis were the independent risk factors of prognosis.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2016年第1期42-45,共4页
Journal of Practical Obstetrics and Gynecology
关键词
年轻宫颈癌
临床特点
术后复发
预后
Young cervical cancer
Clinical characteristics
Postoperative recurrence
The prognosis
