摘要
目的探讨枯草杆菌二联活菌肠溶胶囊对肝脏储备功能不同的肝硬化患者的肠道屏障功能与Th9细胞表达的影响。方法在我院选取172例肝硬化患者作为研究对象,根据肝脏储备功能不同分为Child-Pugh A级(观察组)72例与Child-Pugh B-C级(对照组)100例,所有患者都在常规治疗手段的基础上加用美常安(枯草杆菌二联活菌肠溶胶囊)治疗,都治疗观察14 d。结果对比治疗后两组患者总有效率观察组与对照组的分别为98.6%和89.0%,观察组优于对照组(P<0.05)。两组治疗前肠道菌群比较无明显差异(P>0.05);双歧杆菌属及乳酸杆菌属在观察组中治疗后较治疗前有明显增加(P<0.05),但和治疗前相比,白色念珠菌属有明显的降低(P<0.05),比较对照组治疗前后肠道菌群变化无明显差异(P>0.05)。对比两组治疗后血清IL-6与TNF-α值,观察组与对照组均低于治疗前(P<0.05),且治疗后观察组低于对照组(P<0.05)。治疗后观察组与对照组的Th9细胞分别为(0.11±0.05)%和(0.32±0.10)%(P<0.05),都低于治疗前的(0.82±0.32)%和(0.83±0.24)%,观察组治疗后Th9细胞低于对照组(P<0.05)。结论相对于肝脏储备功能差的患者,枯草杆菌二联活菌肠溶胶囊在肝脏储备功能良好的肝硬化患者中的应用能改善肠道屏障功能,抑制Th9细胞表达,抑制炎症因子的表达,从而更好的发挥治疗效果。
Objective To investigate the effects of Bacillus subtilis and enterococcus faecium enteric-coated capsules on intestinal barrier function and Th9 cell expression in cirrhotic patients with different liver reserve function.Methods A total of 172 patients with liver cirrhosis in our hospital were selected and assigned to observation group(72 children Pugh A grad)and control group(100 children Pugh B-C grade)based on different liver reserve functions.All patients were treated with conventional treatment in addition to the use of metoprolol(Bacillus subtilis enteric coated capsules),and both were observed for 14 days.Results After treatment,the total effective rates in the observation group and the control group were 98.6% and 89%,and the observation group was better than that of the control group(P<0.05).there was no significant difference in intestinal flora between the two groups before treatment(P>0.05),the Bifidobacterium and Lactobacillus in the observation group after treatment were significantly increased(P<0.05),Candida albicans was significantly lower than that before treatment(P<0.05).after treatment,the serum IL-6 and TNF-α in the observation group and the control group were lower than before treatment(P<0.05),and the serum IL-6 and TNF-α in the observation group after treatment were lower than those in the control group(P<0.05).after treatment,the Th9 cells in the observation group and the control group were(0.11±0.05)% and(0.32±0.10)%(P<0.05),respectively,which were lower than(0.82±0.32)% and(0.83±0.24)%before treatment,and the Th9 cells in the observation group after treatment was lower than those in the control group(P<0.05).Conclusion Compared with patients with poor hepatic reserve function,application of Bacillus subtilis and enterococcus faecium enteric-coated capsule in the better hepatic reserve function patients with liver cirrhosis could improve the intestinal barrier function,inhibit the expression of Th9 cells,inhibit the expression of inflammatory cytokines,which play a better therape
作者
张笑丹
梁平
梁倞
王洪博
苏江卫
ZHANG Xiaodan;LIANG Ping;LIANG Jing;WANG Hongbo;SU Jiangwei(Department of Pharmacy,Hebei Chest Hospital,Shijiazhuang 050041,China;Department of Pharmacy,the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China;不详)
出处
《实用医学杂志》
CAS
北大核心
2023年第14期1820-1824,共5页
The Journal of Practical Medicine
基金
河北省医学科学研究课题计划(编号:20230877)。
关键词
肝脏储备功能
枯草杆菌二联活菌肠溶胶囊
肝硬化
肠道屏障功能
TH9细胞
hepatic reserve function
bacillus subtilis and enterococcus faecium enteric-coated capsules
liver cirrhosis
intestinal barrier function
Th9 cells
