摘要
目的:观察与探究调节肠道微生态疗法在肝硬化自发性腹膜炎患者中的应用效果。方法:选取2018年7月-2020年7月80例肝硬化自发性腹膜炎患者作为研究对象,随机分为对照组和研究组,每组40例。对照组进行常规抗感染治疗,研究组在对照组的基础上加用乳果糖和双歧杆菌四联活菌片治疗。比较两组治疗3、5、7、10 d的总有效率,治疗前后的炎症指标(PCT、CRP、WBC、NE%)及肝功能指标(ALT、AST、TBIL、ALB)水平。结果:研究组治疗3、5、7、10 d的总有效率均显著高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组炎症指标、肝功能指标比较,差异均无统计学意义(P>0.05);治疗3、5、7、10 d,研究组炎症指标及ALT、AST、TBIL均显著低于对照组,ALB均显著高于对照组,差异均有统计学意义(P<0.05)。结论:调节肠道微生态疗法在肝硬化自发性腹膜炎患者中的应用效果较好,有助于患者炎症反应的控制及肝功能指标的改善,因此在肝硬化自发性腹膜炎患者中的应用价值较高。
Objective:To observe and investigate the application effect of regulating intestinal microecological therapy in patients with spontaneous peritonitis of liver cirrhosis.Method:A total of 80 patients with spontaneous peritonitis of liver cirrhosis from July 2018 to July 2020 were selected as the study objects,they were randomly divided into the control group and the study group,40 cases in each group.The control group was treated with routine anti-infective therapy,the study group was treated with Lactulose and Bifidobacterium Tetravaccine Tablets.Then total effective rates at the third,fifth,seventh and tenth day after treatment,inflammatory indexes (PCT,CRP,WBC and NE%) and liver function indexes (ALT,AST,TBIL and ALB) levels before and after treatment of two groups were compared.Result:The total effective rates of the study group at the third,fifth,seventh and tenth day after treatment were significantly higher than those of the control group,there were statistically significant differences (P<0.05).The inflammatory indexes and liver function indexes of two groups before treatment were compared,there were no statistically significant differences (P>0.05);the inflammatory indexes and ALT,AST,TBIL of the study group at the third,fifth,seventh and tenth day after treatment were significantly lower than those of control group,the ALB were significantly higher than those of the control group,there were statistically significant differences (P<0.05).Conclusion:The application effect of regulating intestinal microecological therapy in patients with spontaneous peritonitis of liver cirrhosis is better,and it is helpful to control the inflammatory response and improve the indexes of liver function,so its application value in patients with spontaneous peritonitis of liver cirrhosis is higher.
作者
唐岚
梁洁玲
王鹏
钟备
邓英
TANG Lan;LIANG Jieling;WANG Peng;ZHONG Bei;DENG Ying(The Sixth Affiliated Hospital of Guangzhou Medical University(Qingyuan People’s Hospital),Qingyuan 511500,China;不详)
出处
《中国医学创新》
CAS
2021年第32期23-27,共5页
Medical Innovation of China
基金
2018年清远市社会发展领域自筹经费科技计划项目(2018B034)。
关键词
调节肠道微生态疗法
肝硬化自发性腹膜炎
炎症反应
肝功能
Regulating intestinal microecological therapy
Spontaneous peritonitis of liver cirrhosis
Inflammatory reaction
Liver function
