摘要
目的分析白介素⁃6(IL⁃6)、基质细胞衍生因子⁃1(SDF⁃1)、血浆内皮素(ET)与急性脑梗死(ACI)患者重组组织型纤溶酶原激活剂(rt⁃PA)静脉溶栓后预后的关系。方法选取武汉市红十字会医院自2020年3月至2022年3月期间接收的151例行rt⁃PA静脉溶栓后的ACI患者,将其设置为观察组,选取同期体检的健康人群162名作为对照组,比较两组IL⁃6、ET、SDF⁃1水平。根据治疗后1个月的改良Rankin量表结果将观察组患者分为预后良好组和预后不良组,使用Logistic回归分析影响患者rt⁃PA静脉溶栓后预后危险因素。结果观察组IL⁃6、SDF⁃1、ET水平均高于对照组,差异有统计学意义(P<0.05)。预后良好组的患者112例,预后不良组的患者39例,两组的年龄、性别、吸烟饮酒史、高血压、冠心病、TOAST分型、Fib水平比较差异无统计意义(P>0.05),NIHSS、GCS评分及IL⁃6、SDF⁃1、ET、HbAlc、D⁃D指标比较差异具有统计学意义(P<0.05)。多元Logistic回归分析结果显示,血清IL⁃6、SDF⁃1、ET水平及NIHSS、GCS评分是ACI患者静脉溶栓后预后不良的独立危险因素(P<0.05)。结论IL⁃6、ET、SDF⁃1的异常表达与ACI患者静脉溶栓后预后不良密切相关,对三者进行有效检测,可为选择合理治疗方案提供可靠依据,从而改善患者预后情况。
Objective To analyze the relationship between interleukin⁃6(IL⁃6),stromal cell⁃de⁃rived factor⁃1(SDF⁃1),plasma endothelin(ET)and prognosis of recombinant tissue plasminogen activator(rt⁃PA)in patients with acute cerebral infarction(ACI)after intravenous thrombolysis.Methods 151 ACI patients who received rt⁃PA intravenous thrombolysis admitted to Wuhan Red Cross Society Hospital from March 2020 to March 2022 were selected,and were set as the observation group,another 162 healthy people who underwent physical examination during the same period were selected as the control group,the levels of IL⁃6,ET and SDF⁃1 were compared between the two groups.According to the results of modified Rankin scale after 1 month of treatment,the patients in the observation group were divided into the good prognosis group and the poor prognosis group,Logistic regression analysis was used to analyze the risk factors affecting the prognosis of patients after intravenous thrombolysis with rt⁃PA.Results The levels of IL⁃6,SDF⁃1 and ET in the observation group were higher than those in the control group,the difference was statistically signifi⁃cant(P<0.05).There were 112 patients in the good prognosis group and 39 patients in the poor prognosis group,and there were no significant differences in age,gender,smoking and drinking history,hypertension,coronary heart disease,TOAST classification and Fib levels between the two groups(P>0.05),there were statis⁃tically significant differences in NIHSS,GCS scores and IL⁃6,SDF⁃1 and ET,HbAlc and D⁃D indexes between the two groups(P<0.05).Multivariate logistic regression analysis showed that serum IL⁃6,SDF⁃1 and ET lev⁃els,NIHSS and GCS scores were independent risk factors for poor prognosis in ACI patients after intravenous thrombolysis(P<0.05).Conclusion The abnormal expression of IL⁃6,ET and SDF⁃1 is closely related to the poor prognosis of ACI patients after intravenous thrombolysis.Effective detection of these three factors can pro⁃vide reliable basis
作者
韩泉
魏莱
胡彩英
HAN Quan;WEI Lai;HU Caiying(Department of Public Health,Wuhan Red Cross Hospital,Wuhan,Hubei,China,430000;Department of Cardiovascular Medicine,Wuhan Red Cross Hospital,Wuhan,Hubei,China,430000;Department of Internal Medicine,Wuhan Red Cross Hospital,Wuhan,Hubei,China,430000)
出处
《分子诊断与治疗杂志》
2023年第7期1191-1194,1198,共5页
Journal of Molecular Diagnostics and Therapy
基金
武汉市医学科研项目(WZ21A02)。
