摘要
目的探讨丁苯酞联合阿托伐他汀钙治疗急性脑梗死(ACI)患者临床疗效及可能作用机制。方法我院收治的ACI患者125例,采用随机数字表法分为观察组63例与对照组62例。在常规对症治疗的基础上,对照组给予阿托伐他汀钙治疗,观察组给予丁苯酞联合阿托伐他汀钙治疗。治疗2周末,比较两组临床疗效、血清炎性因子、脑神经递质等指标。结果观察组有效率高于对照组(P<0.05);血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)含量低于对照组(P<0.01);γ-氨基丁酸(GABA)、乙酰胆碱(Ach)、谷氨酸(Glu)脑电S谱值低于对照组,多巴胺(DA)脑电S谱值高于对照组(P<0.05)。结论丁苯酞联合阿托伐他汀治疗有助于提高ACI患者临床疗效,可能与拮抗炎症反应、改善脑内神经递质水平等因素有关。
Objective To investigate the clinical efficacy and possible mechanism of butylphthalide combined with atorvastatin calcium in the treatment of patients with acute cerebral infarction(ACI).Methods One hundred and twenty-five patients with ACI in our hospital were divided into observation group(n=63)and control group(n=62).On the basis of conventional symptomatic treatment,the control group was given atorvastatin calcium therapy while the observation group was given butylphthalide combined with atorvastatin calcium therapy.After 2 weeks of treatment,the clinical efficacy,serum inflammatory factors,and brain neurotransmitters were compared between two groups.Results The effective rate in the observation group was higher than that in the control group(P<0.05).Serum IL-6,TNF-αand hs-CRP in the observation group was lower than those in the control group(P<0.01).The EEG S-spectrums of gamma aminobutyric acid(GABA),acetylcholine(ACh)and glutamic acid(Glu)were lower and EEG S-spectrum of dopamine(DA)was higher in the observation group than those in the control group(P<0.05).Conclusion Butylphthalide combined with atorvastatin calcium help to improve the clinical efficacy of ACI patients.The mechanism may be related to antagonistic inflammatory response and improvement of brain neurotransmitters levels.
作者
王月娟
冯士轩
胡瑾
宋征宇
WANG Yue-juan;FENG Shi-xuan;HU Jin;SONG Zheng-yu(The First Affiliated Hospital,Hebei North University,Zhangjiakou 075000,China)
出处
《实用医院临床杂志》
2021年第1期23-26,共4页
Practical Journal of Clinical Medicine
基金
河北省医学科学研究课题计划(编号20200549)。
关键词
急性脑梗死
丁苯酞
阿托伐他汀钙
炎性因子
神经递质
Acute cerebral infarction
Butyphthalide
Atorvastatin calcium
Inflammatory factors
Neurotransmitter
