摘要
目的探讨血清IL⁃17A、miR⁃342⁃3p与2型糖尿病肾病严重程度及预后的关系。方法选取2019年1月至2021年12月东方市人民医院内分泌科收治的119例2型糖尿病患者为研究对象。根据糖尿病肾病发生情况将患者分为对照组(单纯2型糖尿病,n=49)和糖尿病肾病组(发生糖尿病肾病,n=70),并根据白蛋白尿分期和CKD分期并将糖尿病肾病组患者分为G1A2组(n=12)、G2A2组(n=14)、G3A3组(n=17)、G4A3组(n=16)和G5A3组(n=11)等5个亚组。检测比较六组血清IL⁃17A、miR⁃342⁃3p水平,分析血清IL⁃17A、miR⁃342⁃3p水平与UACR和肾小球滤过率的关系。糖尿病肾病患者均随访至2022年11月30日,统计患者随访期间肾存活情况,并将患者分为肾存活组(n=49)和肾非存活组(n=21)。分析血清IL⁃17A、miR⁃342⁃3p水平对2型糖尿病肾病预后的影响及其对2型糖尿病肾病预后的预测效能。结果不同糖尿病肾病病情患者血清IL⁃17A、miR⁃342⁃3p水平比较:G5A3组<G4A3组<G3A3组<G2A2组<G1A2组<对照组,差异有统计学意义(F=9.158,38.244,均P<0.05)。Pearson相关分析结果显示,患者血清IL⁃17A、miR⁃342⁃3p水平与UACR均呈负相关(r=-0.879,-0.883,均P<0.001),但与其肾小球滤过率相关性不明显(r=0.338,0.286,P=0.592,0.704)。肾非存活组血清IL⁃17A、miR⁃342⁃3p水平均低于肾存活组,差异有统计学意义(t=5.997,5.194,均P<0.001)。Logistics回归模型分析结果显示,血清IL⁃17A和miR⁃342⁃3p水平均可明显影响患者预后[OR(95%CI)=(0.2300.111~0.478),0.212(0.096~0.470)]。ROC曲线分析结果显示,2型糖尿病肾病患者血清IL⁃17A和miR⁃342⁃3p水平的预后预测效能均良好,两者联合预测预后效能最佳。结论2型糖尿病肾病患者IL⁃17A和miR⁃342⁃3p表达水平均下调且均与病情严重程度和预后相关,可能作为其病情和预后早期评估参考指标。
Objective To investigate the relationship between serum IL⁃17A,miR⁃342⁃3p with the illness severity and prognosis of type 2 diabetes nephropathy.Methods 119 patients with type 2 diabetes who were admitted to the Department of Endocrinology of Dongfang People's Hospital from January 2019 to December 2021 were selected.According to the occurrence of diabetes nephropathy,the patients were divided into the control group(simple type 2 diabetes,n=49)and the diabetes nephropathy group(diabetes nephropathy,n=70),and according to the albumin urine stage and CKD stage,the patients in the diabetes nephropathy group were divided into five subgroups:G1A2 group(n=12),G2A2 group(n=14),G3A3 group(n=17),G4A3 group(n=16)and G5A3 group(n=11).The levels of serum IL⁃17A,miR⁃342⁃3p in the 6 groups were detected and compared,and the relationship between the levels of serum IL⁃17A,miR⁃342⁃3p with UACR and glomerular filtration rate were analyzed.All patients with diabetes nephropathy were followed up until November 30,2022.The renal survival of the patients during the follow⁃up period was counted,and the patients were divided into renal survival group(n=49)and renal non survival group(n=21).The influence of serum IL⁃17A and miR⁃342⁃3p levels on the prognosis of type 2 diabetes nephropathy and their predictive efficacy on the prognosis of type 2 diabetes nephropathy were analyzed.Results Comparison of serum IL⁃17A and miR⁃342⁃3p levels in patients with different conditions of diabetes nephropathy,G5A3 group<G4A3 group<G3A3 group<G2A2 group<G1A2 group<control group(F=9.158,38.244,P<0.05).Pearson correlation analysis showed that serum IL⁃17A,miR⁃342⁃3p levels were negatively correlated with UACR(r=-0.879,-0.883,P<0.001),but they had no significant correlation with glomerular filtration rate(r=0.338,0.286,P=0.592,0.704).The levels of serum IL⁃17A and miR⁃342⁃3p in the renal non survival group were lower than those in the renal survival group,and the differences were statistically significant(t=5.9
作者
周健飞
陈泰起
龙尚丽
刘晓英
ZHOU Jianfei;CHEN Taiqi;LONG Shangli;LIU Xiaoying(Department of Endocrinology,Dongfang People's Hospital,Dongfang,Hainan,China,572600)
出处
《分子诊断与治疗杂志》
2023年第5期737-741,共5页
Journal of Molecular Diagnostics and Therapy
基金
海南省卫生健康行业科研项目(20A200372)。
