摘要
帕金森病(Parkinson’s disease,PD)是与年龄相关的神经退行性疾病,在世界范围内的患病率越来越高。在没有治愈性治疗的情况下,目前的研究通过识别早期神经变性的微妙变化来预防。最近,已经有研究表明,在双任务条件下(即同时执行认知和步态任务)步态障碍的恶化可能是PD的特征。本文的目的旨在研究不同双任务对筛查PD的研究进展,通过分析本文作者认为不同双任务对筛查PD效果不同并存在先后机制,导致PD前驱期中双任务相关步态变化的机制可能是涉及认知灵活性和步态自动性的额叶-纹状体网络存在缺陷。在未来临床研究中不但需要审查现有双任务研究的利弊选取最佳模式,还需要确定步态控制中代表PD前驱期敏感性和特异性“步态特征”的方面。
Parkinson's disease(PD)is an age-related neurodegenerative disease with an increasing prevalence worldwide.So far,a curative treatment of PD is lacked,which can only be prevented by identifying subtle changes in the early stage of neurodegeneration.Recently,dual task(cognitive and gait tasks)on gait performance aggravation have been considered as the characteristic of PD.This study aims to review research progress of dual-task conditions in the early screening of PD.We believed that a sequential mechanism was responsible for the varied outcomes of PD by different dual-task screening.Defects in the frontostriatal circuits involving cognitive flexibility and gait automaticity were believed as the cause of gait performance changes in the dual tasks of prodromal phase of PD.In the further research,advantages and disadvantages of existed dual-task should be reviewed to select an optimal one for PD screening.Besides,gait characteristics are needed to be identified that represented the sensitivity and specificity during the prodromal phase of PD.
作者
房依婷
黄雨琦
于幸
刘悦文
FANG Yi-ting;HUANG Yu-qi;YU Xing;LIU Yue-wen
出处
《中国疗养医学》
2023年第6期591-594,共4页
Chinese Journal of Convalescent Medicine
基金
教学改革专项课题(A3-0200-22-309009)
校级科研基金自然一般项目(SSF-22-03-002)。
关键词
帕金森
双任务
神经性疾病
步态控制
Parkinson
Dual-task
Neurological disorders
Gait control
