摘要
目的探究承德地区无偿献血者丙型肝炎病毒(Hepatitis C virus,HCV)感染情况和危险因素。方法选取2018年至2019年承德地区无偿献血者血样共77886人进行检测。分析承德地区无偿献血者血液检测情况、HCV感染及合并丙氨酸转氨酶(alanine aminotransferase,ALT)不合格情况,单因素分析HCV感染合并丙氨酸转氨酶(ALT)不合格情况影响因素,采用logistic回归分析无偿献血者HCV检测结果的危险因素,分析其HCV感染与ALT不合格发生的相关性。结果77886人无偿献血者的血液检测不合格率为4.58%,2018和2019年血液检测不合格率分别为4.59%和4.56%,其中ALT不合格率最高,为3.13%。2018和2019年无偿献血者血液检测抗-HCV和ALT不合格率比较,差异无统计学意义(P>0.05);抗-HCV阳性者ALT不合格率为2.99%,是抗-HCV阴性者ALT不合格率0.59%的5.03倍(P<0.05);男性和女性血液检测抗-HCV阳性无显著差异(P>0.05);男性ALT不合格率和抗-HCV合并ALT不合格率显著高于女性(P<0.05);logistic回归分析显示,男性、已婚、1次献血和ALT异常是HCV感染的主要危险因素(P<0.05);HCV感染与ALT异常存在显著相关性(P<0.05)。结论目前临床试剂无法检测出所有的HCV慢性感染者,其中男性、年龄≥45岁、已婚、1次献血和ALT异常是HCV感染的主要危险因素。在今后献血工作,相关部门应加大对男性、年龄≥45岁、已婚、1次献血和ALT阳性无偿献血者的筛查力度,并建立一支低危、固定的无偿献血者队伍,才能不断提高血液安全。
Objective To explore the Hepatitis C virus(HCV)infection and risk factors of unpaid blood donors in Chengde Area.Methods A total of 77886 blood samples from unpaid blood donors in Chengde from 2018 to 2019 were selected for testing.The blood test,HCV infection and alanine aminotransferase(ALT)unqualified situation of voluntary blood donors in Chengde Area were analyzed.Univariate analysis was used to analyze the influencing factors of HCV infection combined with ALT unqualified situation.Logistic regression was used to analyze the risk factors of HCV test results in voluntary blood donors,and the correlation between HCV infection and ALT unqualified was analyzed.Results Among 77886 unpaid blood donors,the unqualified rate of blood testing was 4.58%,and the unqualified rates in 2018 and 2019 were 4.59%and 4.56%,respectively.Among them,the unqualified rate of ALT was the highest,which was 3.13%.There was no statistically significant difference between the anti-HCV and ALT unqualified rates in blood tests in 2018 and 2019(P>0.05).The ALT unqualified rate among anti-HCV positive individuals was 2.99%among anti-HCV negative individuals,5.03 times of the ALT unqualified rate,which was 0.59%(P<0.05).There was no significant difference between male and female anti-HCV positive(P>0.05).The male ALT unqualified rate and the anti-HCV combined ALT unqualified rate were significantly higher than that of females(P<0.05).Logistic regression analysis showed that male,the married,blood donation for one time,and ALT positive were the main risk factors for HCV infection(P<0.05).There was a significant correlation between HCV infection and ALT positive(P<0.05).Conclusion At present,clinical reagents cannot detect all HCV carriers.Male,age≥45 years,the married,one-time blood donation and abnormal ALT are the main risk factors for HCV infection.Therefore,in the future blood donation work,more attention should be paid to males,age≥45 years,the married,one-time blood donation and ALT positive voluntary blood donor screening efforts,
作者
艾心
李松
陈利娜
张旭霞
张莉
AI Xin;LI Song;CHEN Lina;ZHANG Xuxia;ZHANG Li(Chengde CDC Safety Office,Hebei 067000,China;不详)
出处
《医学动物防制》
2023年第4期357-361,共5页
Journal of Medical Pest Control
基金
承德市科学技术研究与发展计划项目(202006A016)。
