摘要
目的 探讨丹参多酚酸盐联合替格瑞洛对冠心病患者的疗效及对血管内皮功能、血脂及氧化应激指标的影响。方法 收集该院2018年1月—2019年12月就诊的112例冠心病患者,根据随机分配的原则分为联合组和参照组各56例,给予参照组患者常规治疗,并注射丹参多酚酸盐治疗,联合组在参照组治疗基础上予以替格瑞洛片口服,对患者炎症因子、氧化应激指标、内皮功能和血脂及疗效、不良反应进行对比。结果 治疗前,两组患者一般指标比较,P>0.05;经治疗后两组患者MDA、AGEs、AOPP、TG、TC、LDL-C、ET-1、MDA、IL-6、CRP、MPO、TNF-α、sCD40L水平均较前下降,且联合组低于参照组,两组SOD、NO水平均较前上升,且联合组高于参照组,差异具有统计学意义(P<0.05)。联合组治疗有效率高于参照组,差异具有统计学意义(P<0.05)。联合组不良反应发生率高于参照组,差异无明显统计学意义(P>0.05)。结论 冠心病患者采取丹参多酚酸盐与替格瑞洛治疗效果显著,患者血管内皮功能、血脂及氧化应激指标均得以改善,值得应用。
Objective To investigate the effect of Salvia Miltiorrhiza polyphenolate combined with tigrillo on vascular endothelial function, blood Lipid and oxidative stress in patients with coronary heart disease.Methods A total of 112 patients with coronary heart disease admitted to the Department of Cardiology of the hospital from January 2018 to December 2019 were collected.According to the principle of random allocation, they were divided into the combination group and the control group, 56 patients in each group were given routine treatment and salvianolate injection.The combination group was given Ticagrelor Tablets orally on the basis of the treatment of the control group.Inflammatory factors, oxidative stress index, endothelial function and blood lipid, efficacy and adverse reactions were compared.Results Before treatment, the general indicators of the two groups were not significant(P>0.05).After treatment, the levels of malondialdehyde(MDA),advanced glycation end products(AGEs),advanced protein oxidation products(AOPP),triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),endothelin-1(ET-1),interleukin-6(IL-6),C-reactive protein(CRP),myeloperoxidase(MPO),tumor necrosis factor-α(TNF-α)and soluble CD40 ligands(CD40L)in two groups were all lower than those before treatment, and the levels of superoxide dismutase(SOD)and nitric oxide(NO)in two groups were higher than those before treatment, and the levels of SOD and NO in two groups were higher than those in the combination group.The difference was statistically significant(P<0.05).The effective rate in the combination group was higher than that in the reference group, and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the combination group was higher than that in reference group, and the difference was not statistically significant(P>0.05).Conclusion The effect of salvianolate combined with ticagrelor on coronary heart disease patients is significant, and the vascular endothelial function, blo
作者
王奕
王志方
刘志强
张晓光
WANG Yi;WANG Zhifang;LIU Zhiqiang;ZHANG Xiaoguang(Xinxiang Central Hospital,The Fourth Clinical College of Xinxiang Medical College,Xinxiang 453000,Henan,China)
出处
《辽宁中医杂志》
CAS
2023年第2期98-102,共5页
Liaoning Journal of Traditional Chinese Medicine
基金
河南省科技攻关项目(212102310812)。
关键词
冠心病
替格瑞洛
丹参多酚酸盐
炎症因子
氧化应激
内皮功能
coronary heart disease(CHD)
tigrillo
Salvia Miltiorrhiza polyphenolate
salvianolate
inflammatory factors
oxidative stress
endothelial function
