摘要
电致化学发光分析法因其具有灵敏度高、线性范围宽的特点,常常应用于物质的分析检测当中。Cu_2WS_4纳米晶是一种新型的三元金属硫化物半导体材料,研究表明其具有过氧化氢模拟酶的性质,但在电致化学发光领域的研究较少。故该文基于Cu_2WS_4纳米晶,制备了一个直接型电致化学发光免疫传感器用于灵敏检测甲胎蛋白(AFP)。研究表明Cu_2WS_4纳米晶是能显著提高发光材料N-(4-氨丁基)-N-乙基异鲁米诺(ABEI)的电致化学发光信号强度,且所构建的传感器对AFP的检测表现出良好的线性关系以及表现出较好的稳定性和选择性。因此,该基于Cu_2WS_4纳米晶的传感器可扩展到其他严重疾病标志物的灵敏检测,为疾病的早期诊断提供新的检测方法。
Because of its high sensitivity and wide linear range,electrochemiluminescence analysis is often used in the analysis of substances.Cu2WS4 nanocrystalline is a new type of ternary metal sulfide semiconductor material.Studies have shown that it has the properties of catalase mimicking enzyme,but there are few studies in the field of electroluminescence.Therefore,in this work a direct electrochemiluminescence immunosensor based on Cu2WS4 nanocrystals is developed for the sensitive detection of alpha fetoprotein(AFP).The results show that Cu2WS4 nanocrystals can significantly improve the electroluminescent signal intensity of N-(4-aminobutyl)-n-ethylisoluminol(ABEI),and the constructed sensor has a good linear relationship,stability and selectivity for the detection of AFP.Therefore,the sensor based on Cu2WS4 nanocrystalline can be extended to the sensitive detection of other serious disease markers,providing a new detection method for early diagnosis of diseases.
作者
蒋欣亚
赵轩
王会军
Jiang Xin-ya;Zhao Xuan;Wang Hui-jun(College of Chemistry and Chemical Engineering,Yangtze Normal University,Chongqing 408100,China)
出处
《化学传感器》
CAS
2021年第3期56-60,共5页
Chemical Sensors
基金
国家自然科学基金青年基金项目(21904013)
重庆市自然科学基金(cstc2021jcyj-msxmX0026)
重庆市教委科学技术研究项目(KJQN202101427)。
