摘要
肝细胞癌目前仍是威胁人民健康的严重疾病。首诊时大部分患者病期较晚,已失去根治性手术机会。传统内科药物治疗及放射治疗效果不佳,肝细胞癌治疗陷入瓶颈。随着以酪氨酸激酶抑制剂为代表的靶向治疗和以程序性死亡受体-1抗体、程序性死亡配体-1抗体为代表的免疫治疗出现,肝细胞癌治疗进入一个崭新时代,为晚期肝细胞癌患者带来新希望。以靶向、免疫为代表的系统治疗不但使晚期肝细胞癌患者生存极大改善,同时也使肝细胞癌的治疗理念不断改变,从单一药物治疗,到多种手段的联合治疗。肝细胞癌的治疗已经从外科为王的时代转变为外科为主的全程管理、综合治疗时代。笔者回顾既往研究,总结自身经验,详细阐述靶向联合免疫治疗时代以外科为主的肝细胞癌综合治疗策略。
Hepatocellular carcinoma is still a severe threat to people′s health of China.Most patients have advanced disease at the time of first diagnosis and lose the opportunity of radical surgery.In the past,the traditional medical drug treatment and radiotherapy are ineffective,which make the treatment of hepatocellular carcinoma into a bottleneck.With the emergence of target therapy represented as tyrosine kinase inhibitors and immunotherapy represented by programmed death-1 antibody and programmed death-ligand 1 antibody,the treatment of hepatocellular carcinoma has entered a new era and patients with advanced hepatocellular carcinoma have seen a new hope.The systemic therapy represented by target therapy and immunotherapy has not only greatly improved the survival of patients with advanced hepatocellular carcinoma,but also changed the treatment concept of hepatocellular carcinoma from single-drug therapy to combined therapy with multiple means.The treatment of hepatocellular carcinoma has changed from the era of surgery as the king to the era of surgery as the mainstay of whole-process management and comprehensive treatment.The authors review previous studies and their own experience to elaborate on the comprehensive treat-ment strategy for hepatocellular carcinoma based on surgical treatment in the era of targeted therapy and immunotherapy.
作者
蔡建强
张搏伦
毕新宇
Cai Jianqiang;Zhang Bolun;Bi Xinyu(Department of Hepatobiliary Surgery,National Cancer Center,National Cancer Clinical Medical Research Center,Peking Union Medical College Cancer Hospital,Chinese Academy of Medical Sciences,Beijing 100021,China)
出处
《中华消化外科杂志》
CAS
CSCD
北大核心
2023年第2期181-186,共6页
Chinese Journal of Digestive Surgery
基金
国家重点研发计划(2017YFC0908101)
中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-066)。
关键词
肝肿瘤
靶向治疗
免疫治疗
外科治疗
综合治疗
Liver neoplasms
Targeted therapy
Immunotherapy
Surgical treatment
Comprehensive treatment
