摘要
目的探讨孕早中期血红蛋白(Hb)、中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)与脐动脉阻力指数(UA-RI)的不同组合方式预测早发型子痫前期(PE)的价值。方法纳入本院建册并定期产检的1789名孕妇为研究对象,以孕期是否出现早发型PE分为早发型PE组(96名)、正常妊娠对照组(1693名)。对比两组孕早中期血清Hb、NLR、PLR及UA-RI的差异。采用受试者工作特征(ROC)曲线分析血清Hb、NLR、PLR与UA-RI指数在不同组合方式预测早发型PE的效能。结果早发型PE组孕早中期血清Hb、NLR及UA-RI指数高于对照组,PLR低于对照组,差异有统计学意义(P<0.05)。ROC曲线分析显示,Hb+PLR联合UA-RI指数预测孕妇早发型PE的AUC面积最大,其预测敏感度为93.56%、特异度为91.87%,均高于Hb+NLR联合UA-RI指数的敏感度(86.78%)和特异度(85.92%)及NLR+PLR联合UA-RI指数的敏感度(78.43%)、特异度(83.95%)。结论早发型PE患者孕早中期血清Hb水平显著上升、NLR比值明显上升、PLR比值明显降低、UA-RI指数升高,其中Hb+PLR联合UA-RI指数在预测早发型PE的价值较高。
Objective To explore the value of different combinations of hemoglobin(Hb),neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR)and umbilical artery resistance index(UA-RI)in predicting early onset preeclampsia(PE).Methods 1789 pregnant women who were included in the register of our hospital and underwent regular birth examination were divided into early-onset PE group(96)and normal pregnancy control group(1693)according to whether early-onset PE occurred during pregnancy.The differences of serum Hb,NLR,PLR and UA-RI in thefirst and second trimester of pregnancy were compared between the two groups.Receiver operating characteristic(ROC)curve was used to analyze the efficacy of serum Hb,NLR,PLR and UA-RI indices in predicting early-onset PE in different combinations.Results Serum Hb,NLR and UA-RI index in early and middle pregnancy of early-onset PE group were higher than those in control group,while PLR was lower,the difference was statistically significant(P<0.05).ROC curve analysis showed that Hb+PLR combined with UA-RI index predicted the largest AUC area of early-onset PE in pregnant women,with a prediction sensitivity of 93.56%and specificity of 91.87%.The sensitivity(86.78%)and specificity(85.92%)of Hb+NLR combined UA-RI index and sensitivity(78.43%)and specificity(83.95%)of NLR+PLR combined UA-RI index were higher than those of Hb+NLR combined UA-RI index.Conclusion In patients with early-onset PE,the serum Hb level increased significantly,the NLR ratio increased significantly,the PLR ratio decreased significantly,and the UA-RI index increased significantly in thefirst and second trimesters of pregnancy,Among them,Hb+PLR combined with UA-RI index is of high value in predicting early-onset PE.
作者
唐丽
罗建文
韦常志
曾荣芳
Tang Li;Luo Jianwen;Wei Changzhi;Zeng Rongfang(Department of Ultrasound,Yizhou Hospital of Traditional Chinese Medicine,Hechi 546300,China;Department of Clinical Laboratory,Yizhou Hospital of Traditional Chinese Medicine,Hechi 546300,China;Department of Intensive Care Medicine,Yizhou Hospital of Traditional Chinese Medicine,Hechi 546300,China)
出处
《实用妇科内分泌电子杂志》
2022年第26期64-66,共3页
Electronic Journal of Practical Gynecological Endocrinology
基金
广西壮族自治区卫生健康委员会自筹经费科研课题(编号Z20201042)。
关键词
早发型
子痫前期
超声
Early hairstyle
Preeclampsia
Ultrasonic
