摘要
目的探讨血小板淋巴细胞比值(platelet-to-lymphocyte ratio,PLR)对子痫前期(preeclampsia,PE)的诊断和预测价值。方法回顾性分析2015年1月至2018年12月扬州大学医学院附属六合医院114例PE患者和152例健康孕妇(对照组)。分别比较两组PLR、平均血小板体积(mean platelet volume,MPV)、血小板分布宽度(platelet distribution width,PDW)等血小板参数对PE的诊断和预测价值。结果轻度PE和重度PE患者淋巴细胞计数、PDW和MPV均高于对照组,而血小板和PLR均低于对照组;重度PE患者血小板计数和PLR低于轻度PE患者,差异均有统计学意义(P<0.05)。PLR的AUC为0.759(95%CI:0.725-0.791),最佳预测值为161。高PLR组人群入院至分娩时间长于低PLR组(7.3 d vs 14.7 d,P=0.001)。PLR≤116显著增加孕妇PE风险(OR=3.47,95%CI:1.85-6.52)。结论PLR是PE的独立危险因素和严重程度预测因子。
Objective To investigate the value of platelet-to-lymphocyte ratio(PLR)in the diagnosis and prognosis of preeclampsia(PE).Methods A retrospective analysis of 114 PE patients and 152 healthy pregnant women(the control group)in Liuhe Hospital Affiliated to Medical College of Yangzhou University from January 2015 to December 2018.Compared the two groups of platelet parameters such as PLR,mean platelet volume(MPV),platelet distribution width(PDW)and other parameters for the diagnosis and prediction of PE.Results Lymphocyte count,PDW and MVP in patients with mild PE and severe PE were significantly higher than those in control group,while platelet and PLR were significantly lower than those in control group.The platelet count and PLR in severe PE patients were significantly lower than those in mild PE patients,the differences were statistically significant(P<0.05).The AUC of PLR was 0.759(95%CI:0.725-0.791),and the best predictive value was 161.The time from admission to delivery in high PLR group was significantly longer than that in low PLR group(7.3 d vs 14.7 d,P=0.001).PLR≤116 significantly increased PE risk in pregnant women(OR=3.47,95%CI:1.85-6.52).Conclusion PLR is an independent risk factor and severity predictor of PE.
作者
周燕武
蒋志慧
严红梅
董莉
ZHOU Yanwu;JIANG Zhihui;YAN Hongmei;DONG Li(Department of Obstetrics and Cynecology,Liuhe Hospital Affiliated to Medical College of Yanghou University,Nanjing Jiongsu211500;Department of Obstetrics and Cynecology,Zhongda Hospital Affliated to Southeast University,Nanjing Jiangsu210009,P.R.China)
出处
《中国计划生育和妇产科》
2020年第12期57-60,77,共5页
Chinese Journal of Family Planning & Gynecotokology
