摘要
目的:探讨妊娠相关血浆蛋白-A(PAPP-A)、甲胎蛋白(AFP)、游离雌三醇(uE3)、血管内皮生长因子(VEGF)在子痫前期诊断价值及其相关性。方法:选择2017年1月—2018年10月本院子痫前期患者78例作为观察组,同期产前检查并顺利分娩的健康孕妇50例为对照组;分析两组血清PAPP-A、AFP、uE3、VEGF水平及其相关性。结果:观察组血清PAPP-A、AFP、uE3、VEGF水平均低于对照组,且重度子痫前期低于轻度;重度子痫前期早发型PAPP-A、AFP、uE3均高于晚发型,VEGF水平明显低于晚发型(均P<0.05)。子痫前期患者血清PAPP-A与AFP、uE3、VEGF水平均呈正相关关系(P<0.05)。结论:血清PAPP-A、AFP、uE3、VEGF参与了子痫前期的发生发展,可作为辅助检查指标用于子痫前期临床筛选,对临床诊断与预后评估有积极意义。
Objective:To explore the value the levels of pregnancy-associated plasma protein-A(PAPP-A), vascular endothelial growth factor(VEGF), alpha-fetoprotein(AFP), and free estriol(uE3) for dignosing the women with preeclampsia, and to study its correlation. Methods: 78 pregnant women with preeclampsia were selected in study group from January 2017 to July 2018, and 50 healthy pregnant women were selected in control group during the same period. The levels of serum PAPP-A, AFP, uE3 and VEGF, and their correlation were analyzed. Results: The levels of serum PAPP-A, AFP, uE3, and VEGF of women in the study group were significant lower than those of women in the control group, and those of women with severe preeclampsia were significant lower than those of women with mild preeclampsia(P<0.05). The serum levels of PAPP-A, AFP, and uE3 of women with early-onset severe preeclampsia were significant lower than those of women with mild preeclampsia were significant higher than those of women with late-onset severe preeclampsia, but the serum VEGF level of women with early-onset severe preeclampsia was significant lower(all P<0.05). The level of PAPP-A of women with preeclampsia was positively correlated with their AFP level, uE3 level, or VEGF level(P<0.05).Conclusion: Serum PAPP-A, AFP, uE3, and VEGF of pregnant women are involved in the occurrence and development of preeclampsia, which can be used as an auxiliary examination index for clinical screening of preeclampsia, and have positive significance for clinical diagnosing and evaluating the prognosis of preeclampsia.
作者
张颖
李永敬
王东辉
ZHANG Ying;LI Youngling;WANG Donahue(Liaoching Maternal and Child Health Care Hospital,Shandong Province,252000;Dongchangfu District Maternal and Child Health Care Hospital of Liaocheng City,Shandong Province)
出处
《中国计划生育学杂志》
2020年第7期1129-1131,共3页
Chinese Journal of Family Planning
