摘要
目的研究妊娠期高血压和产妇发生易栓症的关系。方法选取50例妊娠期高血压产妇作为妊娠期高血压组,另选取50例正常妊娠产妇作为正常妊娠组。检测并对比两组产妇的凝血指标(凝血酶原时间、凝血酶时间、活化部分凝血酶原时间、抗凝血酶Ⅲ、纤维蛋白原)、血小板指标(血小板计数、血小板压积、血小板分布宽度、平均血小板体积)及血脂指标(总胆固醇、甘油三酯)水平。结果妊娠期高血压组产妇的活化部分凝血酶原时间(24.7±4.4)s短于正常妊娠组的(28.7±2.4)s,抗凝血酶Ⅲ(94.1±16.0)%低于正常妊娠组的(103.1±18.4)%,纤维蛋白原(4.1±0.6)g/L高于正常妊娠组的(3.6±0.8)g/L,差异有统计学意义(P<0.05);两组产妇的凝血酶时间、凝血酶原时间对比,差异无统计学意义(P>0.05)。妊娠期高血压组产妇的平均血小板体积(11.00±2.34)fl、血小板分布宽度(16.88±0.79)%、甘油三酯(3.27±0.76)mmol/L均高于正常妊娠组的(8.63±2.26)fl、(16.11±0.46)%、(2.81±0.92)mmol/L,差异有统计学意义(P<0.05);两组产妇的总胆固醇、血小板计数、血小板压积对比,差异无统计学意义(P>0.05)。结论产妇易栓症的发生和妊娠期高血压密切相关,临床中妊娠期高血压产妇,特别是严重先兆子痫的产妇接受早期凝血相关指标检测可以帮助产妇及早接受抗凝治疗,促进疾病预后。
Objective To study the correlation between gestational hypertension and the occurrence of maternal thrombophilia.Methods 50 cases of gestational hypertension were included in the gestational hypertension group,and another 50 cases of normal pregnancy were included in the normal pregnancy group.The coagulation indexes(prothrombin time,thrombin time,activated partial thrombin time,antithrombinⅢ,fibrinogen),platelet indexes(platelet count,platelet hematocrit,platelet distribution width,mean platelet volume)and blood lipid indexes(total cholesterol,triglyceride)of the two groups were detected and compared.Results The activated partial thrombin time(24.7±4.4)s in the gestational hypertension group was shorter than(28.7±2.4)s in the normal pregnancy group;the antithrombinⅢ(94.1±16.0)%in gestational hypertension group was lower than(103.1±18.4)%in normal pregnancy group;the level of fibrinogen(4.1±0.6)g/L in gestational hypertension group was higher than(3.6±0.8)g/L in normal pregnancy group;the differences were statistically significant(P<0.05).There was no statistically significant difference between the two groups in terms of prothrombin time and prothrombin time(P>0.05).The mean platelet volume(11.00±2.34)fl,platelet distribution width(16.88±0.79)%,and triglycerides(3.27±0.76)mmol/L in the gestational hypertension group were higher than(8.63±2.26)fl,(16.11±0.46)%,and(2.81±0.92)mmol/L in the normal pregnancy group,and the differences were statistically significant(P<0.05).The total cholesterol,platelet count,and platelet hematocrit in the two groups were compared,and the differences were not statistically significant(P>0.05).Conclusion The development of maternal thrombophilia is closely related to gestational hypertension.Early detection of coagulation related indicators in women with gestational hypertension,especially those with severe preeclampsia,can help them to receive anticoagulant treatment as early as possible and promote the prognosis of the disease.
作者
敖明珠
AO Ming-zhu(Dalian Women and Children Medical Center(Group),Dalian 116000,China)
出处
《中国现代药物应用》
2023年第4期62-64,共3页
Chinese Journal of Modern Drug Application
关键词
妊娠期高血压
易栓症
凝血指标
Gestational hypertension
Thrombophilia
Coagulation index
