摘要
目的探讨安徽地区妇女亚甲基四氢叶酸还原酶(methylenetetrahydrofolate reductase,MTHFR)基因C677位点多态性与复发性自然流产的关系。方法采用PCR-芯片杂交法对108例复发性自然流产患者和181例有正常妊娠史的妇女进行MTHFRC677基因多态性检测。结果复发性自然流产患者MTHFRC677位点TT基因型与对照组相比没有显著性差异(P>0.05),复发性自然流产患者T等位基因与对照组相比也没有显著性差异(P>0.05)。结论 MTHFRC677C>T突变不是安徽地区妇女复发性自然流产的危险因素。
Objective：This study was carried out to determine the influence of methylenetetrahydrofolate reductase gene（MTHFR）C677 polymorphisms in recurrent spontaneous abortion（RSA）women in Anhui province. Methods：A case-control study was performed on 2 groups（181 healthy and 108 RSA women）,and the frequency of the MTHFR C677 polymorphisms was determined by Pcr-Chip hybridization method. Result：Statistical analysis showed there was no significant difference in MTHFR C677 TT type between RSA group and the control group（P〉0.05）,and there was no significant difference in T allele between RSA group and the control group（P〉0.05）. Conclusion：MTHFR C677 CT mutation is not a risk factor for recurrent spontaneous abortion of women in anhui province.
作者
孙玉秀
朱树亮
王朝红
王亚群
童克婷
唐俊湘
朱健生
SUN Yu-xiu;ZHU Shu-liang;WANG Chao-hong;WANG Ya-qun;TONG Ke-ting;TANG Jun-xiang;ZHU Jian-sheng(Genetic Center,Anhui women and Child Health Care Hospital,HeFei,230001)
出处
《中国优生与遗传杂志》
2018年第10期28-29,32,共3页
Chinese Journal of Birth Health & Heredity
基金
安徽省科技计划项目(15011d04053)
关键词
复发性自然流产
亚甲基四氢叶酸还原酶
基因多态性
Recurrent spontaneous abortion
Methylenetetrahydrofolate reductase
Gene polymorphism
