摘要
目的探讨维生素B_(1)(VB_(1))、维生素B_(12)(VB_(12))足三里穴位注射对急性脑梗死患者神经功能、胃肠功能的影响。方法选取80例急性脑梗死患者作为研究对象,采用随机数字表法随机分为对照组(40例,西医内科规范治疗)、研究组(40例,西医内科规范治疗+VB_(1)、VB_(12)足三里穴位注射治疗)。比较2组治疗前后神经功能缺损情况(NIHSS评分)、血清神经元特异性烯醇化酶(NSE)水平、胃肠道生活质量指数(GIQLI)、日常生活活动能力(ADL),评估临床疗效。结果2组治疗后NIHSS评分、NSE水平均低于同组治疗前,差异有统计学意义(P<0.01);研究组治疗后NIHSS评分、NSE水平均低于同期对照组,差异有统计学意义(P<0.05)。2组治疗后GIQLI、ADL评分均高于同组治疗前,差异有统计学意义(P<0.01);研究组治疗后GIQLI、ADL评分均高于同期对照组,差异有统计学意义(P<0.05)。对照组总有效率与研究组比较,组间差异有统计学意义(P<0.05)。结论VB_(1)、VB_(12)足三里穴位注射治疗急性脑梗死,可促进患者缺损神经功能恢复、提高日常生活活动能力;其机制可能与下调NSE水平而抑制脑细胞损伤、改善胃肠道功能相关。
Objective To investigate the effect of Zusanli(ST36)injection of vitamin B_(1)(VB_(1))and vitamin B_(12)(VB_(12))on neurological function and gastrointestinal function in patients with acute cerebral infarction.Methods 80 cases of patients with acute cerebral infarction were randomly divided into control group(40 cases,standard treatment of western medicine)and study group(40 cases,standard treatment of western medicine and VB_(1),VB_(12) Zusanli(ST36)injection).NIHSS score,serum neuron specific enolase(NSE)level,gastrointestinal quality of life index(GIQLI)and activities of daily living(ADL)were compared between the two groups before and after treatment to evaluate the clinical efficacy.Results The NIHSS score and NSE level of the two groups after treatment were lower than those before treatment in the same group(P<0.01);After treatment,NIHSS score and NSE level of the study group were lower than those of the control group(P<0.05).The scores of GIQLI and ADL in the two groups after treatment were higher than those before treatment in the same group(P<0.01);After treatment,the GIQLI and ADL scores of the study group were higher than those of the control group(P<0.05).The total effective rate in the control group and in the study group(P<0.05).Conclusion Zusanli(ST36)injection of VB_(1) and VB_(12) can promote the recovery of neurological function and improve the activities of daily living in patients with acute cerebral infarction;The mechanism may be related to the inhibition of brain cell injury and improvement of gastrointestinal function by down regulating NSE level.
作者
寇志刚
KOU Zhigang(Department of Pain Rehabilitation,Zhengzhou Third People's Hospital,Henan Province,Zhengzhou 450099,China)
出处
《光明中医》
2022年第17期3178-3181,共4页
GUANGMING JOURNAL OF CHINESE MEDICINE
