摘要
目的观察单唾液酸四己糖神经节苷脂联合康复训练治疗脑卒中的临床疗效。方法选取2018年1月-2021年2月在绵阳市中心医院接受治疗的脑卒中病人128例,采用随机数字表法分为观察组(63例)和对照组(65例)。对照组采用常规治疗结合康复训练,观察组在对照组基础上联合单唾液酸四己糖神经节苷脂治疗,比较两组治疗前后血液流变学指标、美国国立卫生研究院卒中量表(NIHSS)评分、平衡与功能性步行能力、血清神经元特异性烯醇化酶(NSE)、中枢神经特异性蛋白(S100β)水平。结果治疗后,观察组血液流变指标血浆黏度、全血高切黏度、全血低切黏度以及血清NSE、S100β水平均低于对照组(P<0.05);治疗后,观察组Berg平衡量表(BBS)、功能性步行量表(FAC)评分均高于对照组(P<0.001);治疗后第1周、第2周,观察组NIHSS评分均低于对照组(P<0.001)。结论单唾液酸四己糖神经节苷脂联合康复训练可明显改善脑卒中病人的平衡与功能性步行能力以及神经功能,促进病人血流动力学恢复正常。
Objective To explore the therapeutic effect of monosialotetrahexosylganglioside(GM1)combined with rehabilitation training on stroke patients.Methods A total of 128 stroke patients were selected,and were divided into observation group and control group by random number table method.The patients in control group were given conventional treatment and rehabilitation training,and the patients in observation group were additionally treated with GM1.The hemorheology index,National Institutes of Health Stroke Scale(NIHSS)score,balance and functional walking ability,serum neuron-specific enolase(NSE),central nervous system specific S100beta protein(S100β)were compared between two groups.Results After treatment,the plasma viscosity,high-shear viscosity,low-shear viscosity,and levels of NSE and S100βin observation group were lower than those in control group(P<0.05).After treatment,the Berg Balance Scale(BBS)scores and Functional Ambulation Category Scale(FAC)scores of observation group were higher than those of control group(P<0.001).At the end of first and second week after treatment,the NIHSS scores of observation group were lower than those of control group(P<0.001).Conclusion GM1 combined with rehabilitation training can significantly improve balance,functional walking ability,and neurological function of stroke patients,and promote the recovery of hemodynamics.
作者
何林
钟琪
HE Lin;ZHONG Qi(Mianyang Central Hospital,School of Medicine,University of Electronic Science and Technology of China,Mianyang 621000,Sichuan,China)
出处
《中西医结合心脑血管病杂志》
2022年第17期3107-3110,共4页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
