摘要
目的:研究益气活血法联合西药治疗对气虚血瘀型慢性心力衰竭(CHF)患者纽约心脏病协会(NYHA)分级及神经内分泌因子水平的影响。方法:纳入2020年3月-2021年8月平潭综合实验区医院治疗的120例气虚血瘀型CHF患者为研究对象,按照随机数字法分为对照组(60例)和观察组(60例),对照组接受常规(琥珀酸美托洛尔缓释片+盐酸贝那普利+氢氯噻嗪)治疗,观察组在对照组基础给予益气活血法治疗,均治疗4周。比较并分析两组心功能指标、治疗效果、NYHA分级、神经内分泌因子水平及药物相关不良反应。结果:治疗后,观察组LVEF显著高于对照组[(48.06±5.20)%vs(40.26±5.18)%],LVEDD[(45.62±2.34)mm vs(52.01±1.39)mm]、LVESD[(39.17±1.62)mm vs(43.93±1.84)mm]均显著低于对照组,观察组治疗效果明显优于对照组(P<0.05);观察组NYHA分级Ⅰ、Ⅱ级明显高于对照组,Ⅲ、Ⅳ级明显低于对照组(P<0.05);观察组治疗后BUN[(6.70±1.40)mmol/L vs(7.30±1.20)mmol/L]、NT-proBNP[(111.95±11.08)pg/ml vs(192.38±20.39)pg/ml]显著低于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:气虚血瘀型CHF患者行益气活血法治疗,能够进一步改善NYHA情况,提升治疗效果。
Objective:To study the effects of Yiqi Huoxue method combined with western medicine therapy on New York Heart Association(NYHA)grading and neuroendocrine factor level of chronic heart failure(CHF)patients with Qi deficiency and blood stasis.Method:A total of 120 CHF patients with Qi deficiency and blood stasis treated in Pingtan Comprehensive Experimental Area Hospital from March 2020 to August 2021 were included as the research objects.They were divided into control group(60 cases)and observation group(60 cases)according to random number method.The control group accepted routine treatment(Succinate Metoprolol Zyban+Benazepril Hydrochloride+Hydrochlorothiazide),the observation group was given Yiqi Huoxue method of treatment on the basis of the control group.All were treated for 4 weeks.Cardiac parameters,therapeutic effect,NYHA grading,neuroendocrine factor levels and drug-related adverse reactions were compared and analyzed between the two groups.Result:After treatment,LVEF of the observation group[(48.06±5.20)%vs(40.26±5.18)%]was significantly higher than that in the control group,LVEDD[(45.62±2.34)mm vs(52.01±1.39)mm],LVESD[(39.17±1.62)mm vs(43.93±1.84)mm]were significantly lower than those in the control group,and the therapeutic effect in the observation group was significantly better than that in the control group(P<0.05).The gradeⅠ,Ⅱof NYHA in observation group were significantly higher than those in control group,while gradeⅢ,Ⅳof NYHA in observation group were significantly lower than those in control group(P<0.05).BUN[(6.70±1.40)mmol/L vs(7.30±1.20)mmol/L],NT-proBNP[(111.95±11.08)pg/ml vs(192.38±20.39)pg/ml]in the observation group were significantly lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:For CHF patients with Qi deficiency and blood stasis,the treatment of Yiqi Huoxue method can further improve NYHA,improve therapeutic effect.
作者
何岚斌
林清
刘桂
HE Lanbin;LIN Qing;LIU Gui(Pingtan Comprehensive Experimental Area Hospital,Pingtan 350400,China;不详)
出处
《中外医学研究》
2022年第16期149-152,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
益气活血法
气虚血瘀型
慢性心力衰竭
神经内分泌因子
Yiqi Huoxue method
Qi deficiency and blood stasis
Chronic heart failure
Neuroendocrine factor
