摘要
目的:研究强心胶囊对慢性心力衰竭(CHF)大鼠心功能和心肌基质金属蛋白酶MMP-1、MMP-9蛋白表达的影响,探讨MMPs在CHF发病中的作用及该胶囊防治心肌重塑的作用的机理。方法:采用腹腔注射阿霉素法制备CHF模型。各组相应处理8周后,检测血流动力学、心肌MMP-1、MMP-9表达变化。结果:强心胶囊能提高CHF大鼠+dp/dt max、-dp/dt max、LVSP水平,降低LVEDP水平,减低心脏重量指数,降低上调的MMP-1、MMP-9表达。结论:强心胶囊能够改善CHF大鼠左室收缩和舒张功能,降低上调的MMP-1、MMP-9蛋白表达及活性,可能是强心胶囊干预心力衰竭间质重塑的重要机制之一。
We studied the effects of Qiangxin Capsule on MMP-1 and MMP-9 expression of matrix metalloproteinase in rats with congestive heart failure, in a move to understand the role of MMPs in CHF, and therapeutic effects of Qiangxin Capsule in remodeling interstitial tissue of cardiac. In the study, we established a rat model intraperitoneally injected with doxorubicin （ADM）. Haemo-dynamics, MMP-1, and MMP-9 were measured 8 weeks after the injection. Results indicate that the Qiangxin Capsule has enhanced the level of ＋dp/dt max, -dp/dt max, and LVSP of CHF rat, with a reduced LVEDP level. Heart weight index has also gone down with declined MMP-1 and MMP-9 expressions and activities. Obviously, the Qiangxin Capsule reduces MMP-1 and MMP-9 expressions and activities, which makes an important mechanism allowing the Qiangxin Capsule to interfere in cardiac failure related interstitial remodeling.
出处
《世界科学技术-中医药现代化》
2008年第2期46-49,共4页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
黑龙江省科技厅科技攻关项目(GC02C123)强心胶囊治疗充血性心力衰竭的基础研究
