摘要
目的 探讨加味行健汤联合TACE对胃癌肝转移患者肿瘤局部控制及血清肝细胞生长因子(HGF)、血管内皮生长因子(VEGF)水平的影响。方法 选取2016年3月至2019年3月89例胃癌肝转移患者,随机数字表法分为对照组(n=44)和实验组(n=45)。对照组给予TACE(1~3次),实验组给予TACE^(+)加味行健汤(4个化疗周期)。观察两组肿瘤局部控制率、不良反应、生活质量改善率及治疗前、TACE治疗后1个月、3个月血清HGF、VEGF水平、T淋巴细胞亚群、炎性因子水平,并于TACE治疗后12个月统计生存率。结果 实验组肿瘤局部控制率为84.44%(38/45),高于对照组65.9%(29/44)(P0.05)。TACE治疗后1个月、3个月实验组血清HGF、VEGF水平低于对照组(P<0.05)。TACE治疗后1个月、3个月实验组CD3^(+)、CD8^(+)、CD4^(+)/CD8^(+)T淋巴细胞水平均优于对照组(P<0.05),实验组免疫功能呈上升趋势,对照组呈下降趋势。TACE治疗后1个月、3个月两组血清IFN-γ、IL-10、IL-2水平均明显改善,实验组改善幅度较高(P<0.05)。实验组生活质量改善率为53.3%(24/45),高于对照组31.8%(14/44)(P<0.05),TACE治疗后12个月随访,两组生存率比较差异无统计学意义。结论 加味行健汤联合TACE治疗胃癌肝转移临床效果显著,可控制肿瘤进展,抑制HGF、VEGF等血清因子表达,同时提高机体免疫功能,缓解机体炎症状态,改善患者生活质量,且安全性良好。
Objective To investigate the effect of Jiaweixingjian decoction,which is a prescription of traditional Chinese herbs,combined with transcatheter arterial chemoembolization(TACE) on the tumor local control and serum levels of hepatocyte growth factor(HGF) and vascular endothelial growth factor(VEGF) in patients with liver metastasis of gastric cancer.Methods A total of 89 patients with liver metastasis of gastric cancer between March 2016 and March 2019 were enrolled in this study.Using random number table method,the patients were divided into control group(n=44) and study group(n=45).The patients of control group were treated with TACE(1-3 procedures),while the patients of study group receive TACE plus Jiaweixingjian decoction(4 cycles of chemotherapy).The tumor local control rate,adverse reactions,improvement rate of life quality,pre-TACE and post-TACE one-month,3-month serum HGF,VEGF levels,T-lymphocyte subsets(including CD3^(+),CD8^(+)and CD4^(+)/CD8^(+)),inflammatory factors including interferon γ(IFN-γ),interleukin-10(IL-10)and interleukin-2(IL-2) were tested,and post-TACE 12-month survival rate was calculated.Results The local control rate of tumor in the study group was 84.44%(38/45),which was significantly higher than 65.9% in the control group(29/44)(P0.05).Post-TACE one-month,3-month serum HGF,VEGF levels in the study group were remarkably lower than those in the control group(P<0.05).Post-TACE one-month,3-month CD3^(+),CD8^(+)and CD4^(+)/CD8^(+)levels in the study group were strikingly better than those in the control group(P<0.05).In both groups the post-TACE one-month,3-month serum levels of IFN-γ,IL-10 and IL-2 were obviously improved,but the degree of improvement in the study group was strikingly higher than that in the control group(P<0.05).The improvement rate of life quality in the study group was 53.3%(24/45),which was prominently higher than 31.8%(14/44)(P<0.05).No statistically significant difference in post-TACE 12-month survival rate existed between the two groups.Conclusion In treating
作者
张建磊
刘震坤
李庆敏
刘固
全凌峰
ZHANG Jianlei;LIU Zhenkun;LI Qingmin;LIU Gu;QUAN Lingfeng(Department of Intervention,Chenzhou Municipal First People’s Hospital,Hunan Province 423000,China)
出处
《介入放射学杂志》
CSCD
北大核心
2022年第4期359-363,共5页
Journal of Interventional Radiology
关键词
胃癌肝转移
加味行健汤
随机对照试验
liver metastasis of gastric cancer
Jiaweixingjian decoction
randomized controlled trial
