摘要
目的:探讨复生康胶囊联合高强度聚焦超声消融术(HIFUA)治疗不可切除的胃癌肝转移的临床治疗效果。方法:运用随机数字表法将226例不可切除的胃癌肝转移患者分为观察组和对照组,各113例。两组均采用HIFUA进行治疗,观察组另给予复生康胶囊,而对照组则给予安慰剂。治疗前后,检测两组患者免疫功能指标,主要包括IgG、IgA、IgM、CD3^+及CD4^+水平;检测两组患者肿瘤标记物含量,主要包括AFU、GP73、CA242及Frr;检测两组患者肝功能指标,主要包括TBIL、AST、ALP及ALT。治疗后,对两组进行为期3年的随访,分别比较两组患者的1年和3年生存率、PFS和OS。结果:治疗后,观察组IgG、IgA、IgM、CD3^+及CD4^+均显著高于对照组(P<0.05),而AFU、GP73、CA242及Frr含量均显著低于对照组,且TBIL、AST、ALP及ALT含量亦均显著低于对照组(P<0.05)。相较于对照组,观察组患者的1年和3年生存率、PFS及OS均显著升高,且差异具有统计学意义(P<0.05)。结论:复生康胶囊联合HIFUA可有效改善不可切除的胃癌肝转移患者的免疫和肝功能,延长患者的生存时间。
Objective:To observe the clinical study of Fushengkang capsules combined high intensity focused ultrasound ablation(HIFUA)in the treatment of unresectable gastric cancer with liver metastases.Methods:A total of 226 patients with unresectable gastric cancer with liver metastases were divided into the observation group and the control group by random number table method,113 cases in each group.The 2 groups were treated by HIFUA,and the observation group and the control group were given Fushengkang capsules and placebo,respectively.Before and after treatment,the immune index(IgG,IgA,IgM,CD3^+ and CD4^+),tumor markers(AFU,GP73,CA242 and Frr),liver function indexs(TBIL,AST,ALP and ALT)of the 2 groups were detected.After the treatment,3 years followup were performed in the 2 groups,and the 1 year survival rate,3 years survival rate,PFS and OS of the 2 groups were compared.Results:After the treatment,the levels of IgG,IgA,IgM,CD3^+ and CD4^+ in the observation group were significantly higher than those in the control group(P<0.05),AFU,GP73,CA242 and Frr were significantly lower than those in the control group(P<0.05),moreover TBIL,AST,ALP and ALT levels were also significantly lower than those in the control group(P<0.05).Compared with the control group,the 1-year and 3-year survival rates,PFS and OS in the observation group were significantly increased,and the difference was statistically significant(P<0.05).Conclusion:Fushengkang capsules combined HIFUA in the treatment of unresectable gastric cancer with liver metastases can effectively promote the immune and liver function,prolong the survival time of patients.
作者
刘鑫
张锦
袁东红
孟存英
谭玉娥
LIU Xin;ZHANG Jin;YUAN Donghong(Department of Gastroenterology,Affiliated Hospital of Yan'an University,Yan’an 716000)
出处
《陕西中医》
2020年第2期164-167,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
陕西省教育厅自然科学研究项目(2013JK0782)
关键词
胃癌肝转移
复生康胶囊
高强度聚焦超声消融术
免疫功能
肝功能
生存时间
Gastric cancer with liver metastases
Fushengkang capsules
High intensity focused ultrasound ablation
Immune function
Liver function
Survival time
