摘要
目的:探讨解毒散结方联合化疗对晚期胃癌患者疗效及对血清血管内皮生长因子-A(VEGF-A)、血管内皮生长因子-D(VEGF-D)、血管内皮生长因子受体-1(VEGFR-1)的影响。方法:选取102例晚期胃癌患者为研究对象,以随机数字表法分为对照组(替吉奥联合奥沙利铂化疗)和观察组(对照组基础上联合解毒散结方治疗),每组均为51例,两组均治疗12周。观察两组临床疗效、治疗前后中医症候评分、血清VEGF-A、VEGF-D、VEGFR-1水平以及治疗期间不良反应发生情况。结果:治疗12周后两组疗效等级分布比较差异显著(P<0.05),且观察组的总有效率高于对照组(P<0.05);治疗12周后两组患者中医症候评分均降低(P<0.05),且观察组更低(P<0.05);治疗12周后,两组血清VEGF-A、VEGFR-1水平均降低(P<0.05),两组血清VEGF-D水平均升高(P<0.05),且观察组血清VEGF-A、VEGFR-1水平更低(P<0.05),观察组血清VEGF-D水平更高(P<0.05);两组不良反应发生率相近(P>0.05)。结论:解毒散结方联合替吉奥联合奥沙利铂化疗用于治疗脾胃虚弱、瘀毒蕴结证晚期胃癌患者能够改善临床症状及血管内皮生长因子水平,疗效显著。
Objective:To explore the curative effect of Jiedu Sanjie recipe combined with chemotherapy on patients with advanced gastric cancer and serum vascular endothelial growth factor-A(VEGF-A),vascular endothelial growth factor-D(VEGF-D),vascular endothelial growth factor receptor-1(VEGFR-1)impact.Methods:A total of 102 patients with advanced gastric cancer were selected as the research objects,they were divided into a control group(with Tiggio combined with oxaliplatin chemotherapy)and an observation group(on the basis of the treatment of the control group,combined with the treatment of Jiedu Sanjie decoction)according to the random number table,each group has 51 cases,and both groups were treated for 12 weeks.The clinical efficacy,Chinese medicine syndrome scores before and after treatment,serum VEGF-A,VEGF-D,and VEGFR-1 levels,and adverse reactions during the treatment period were observed.Results:After 12 weeks of treatment,there was a significant difference in the distribution of curative effect grades between the two groups(P<0.05),and the total effective rate of the observation group was higher than that of the control group(P<0.05);after 12 weeks of treatment,the scores of Chinese medicine symptoms in the two groups were reduced(P<0.05),and the observation group was lower(P<0.05);after 12 weeks of treatment,the serum VEGF-A and VEGFR-1 levels in the 2 groups decreased(P<0.05),and the serum VEGF-D levels in the 2 groups increased(P<0.05),and the observation group’s serum VEGF-A and VEGFR-1 levels were lower(P<0.05),and the observation group’s serum VEGF-D levels were higher(P<0.05);the incidence of adverse reactions in the two groups was similar(P>0.05).Conclusion:Jiedu Sanjie recipe combined with Tiggio and oxaliplatin chemotherapy can improve the clinical symptoms and vascular endothelial growth factor levels in patients with advanced gastric cancer,weakness of the spleen and stomach and stagnation of toxin,with significant curative effect.
作者
蒋峰
柳小芳
高艺文
孙晓虹
蒋士卿
JIANG Feng;LIU Xiaofang;GAO Yiwen;SUN Xiaohong;JIANG Shiqing(Yantai Affiliated Hospital,Binzhou Medical University,Yantai 264100,China)
出处
《陕西中医》
CAS
2021年第5期582-585,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
河南省科技攻关计划项目(082102310028)。
关键词
晚期胃癌
解毒散结方
化疗
血管内皮生长因子-A
血管内皮生长因子-D
血管内皮生长因子-1
Advanced gastric cancer
Jiedu Sanjie recipe
Chemotherapy
Vascular endothelial growth factor-A
Vascular Endothelial growth factor-D
Vascular endothelial growth factor-1
