摘要
目的蒙药瑞香狼毒含有香豆素类、黄酮类、二萜类等多种成分。除传统的逐水杀粘、治痈消肿等功效外,具有抗菌、抗病毒、抗肿瘤、抗惊厥和癫痫、杀虫和免疫调节等多种活性。但由于生品毒性大,经常炮制入药。蒙医在用药过程中不断摸索出瑞香狼毒多种炮制方法,并不断对其进行优化改进,以达到减毒增效的目的。方法本文作者对瑞香狼毒的药理作用、毒性、炮制方法及炮制工艺优化以及不同炮制方法对瑞香狼毒化学成分、药理作用和毒性的影响等方面的文献进行整理综述。结果与结论本文为瑞香狼毒及其制剂的研发和临床应用提供一定的理论参考。
Objective The Mongolian medicine Daphne sinensis contains coumarins,flavonoids,diterpenes and other components.In addition to the traditional efficacy of killing glue by water and treating carbuncle,it has antibacterial,antiviral,anti-tumor,anti-convulsion and epilepsy,insecticidal and immunomodulatory activities.However,because of the high toxicity of raw products,often processed drugs.In the process of drug use,Mongolian medicine has explored a variety of processing methods of Daphne odoriferae and continuously optimized and improved it to achieve the purpose of reducing toxicity and increasing efficiency.Methods In this paper,the pharmacological action,toxicity,processing methods,processing technology optimization and the effects of different processing methods on chemical components,pharmacological action and toxicity of Daphne frondosa were reviewed.Result(s)and Conclusion(s)This paper provides a theoretical reference for the development and clinical application of Stellera chamaejasme and its preparations.
作者
白小红
包文双
胡和珠拉
白梅荣
胡伊力格其
BAI Xiaohong;BAO Wenshuang;Huhezhula;BAI Meirong;Huyiligeqi(School of Mongolian Medicine,Inner Mongolia University for Nationalities,Tongliao 028000;Key Laboratory of Mongolian Medicine RESEARCH and Development,Ministry of Education,Inner Mongolia University for Nationalities,Tongliao 028000)
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2022年第5期624-630,共7页
Journal of Shenyang Pharmaceutical University
基金
内蒙古自然科学基金资助项目(2018LH08063)
内蒙古自然科学基金资助项目(2020LH08013)。
关键词
瑞香狼毒
炮制
化学成分
毒效
Stellera chamaejasme
processing drugs
chemical component
toxic effect
