摘要
目的观察祛瘀化痰法对肝豆状核变性患者神经功能的影响及临床疗效。方法收集2019年1月—2021年6月安徽中医药大学第一附属医院脑病中心住院的痰瘀互结型肝豆状核变性患者60例资料,将60例痰瘀互结型肝豆状核变性患者按随机数表法分为治疗组和对照组,每组30例,治疗2个疗程,观察2组患者治疗前后肝豆状核变性患者神经功能积分和临床疗效以及24 h尿铜情况。结果治疗2个疗程末治疗组和对照组神经功能评分[(25.63±9.06)分、(57.13±12.03)分]均低于治疗前[(64.03±11.41)分、(66.40±13.27)分,均P<0.05],治疗组治疗2个疗程末神经功能评分低于对照组(P<0.05);治疗组临床总有效率更高(93.3%vs.70.0%,χ^(2)=5.455,P=0.020);治疗2个疗程末治疗组和对照组24 h尿铜[(1690.40±369.90)μg/24 h、(1376.75±311.91)μg/24 h]均高于治疗前[(202.33±38.11)μg/24 h、(206.66±38.38)μg/24 h,均P<0.01],治疗组治疗后尿铜较对照组明显升高(P<0.05)。结论祛瘀化痰法能明显改善肝豆状核变性患者的神经功能,改善临床疗效,提高患者的生活质量。
Objective To observe the effect of removing blood stasis and resolving phlegm on the nerve function in patients with Wilson's disease.Methods A total of 60 Wilson's disease patients with phlegm and blood stasis who were hospitalised in the Encephalopathy Center of the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from January 2019 to June 2021 were treated for the research.These patients were randomly divided into treatment group and comparison group according to the random number table method,with 30 patients in each group.The treatment comprised two courses.During the treatment,Wilson's disease neurological function score,clinical efficacy and 24 h urine copper in the two groups were observed.Results At the end of 2 courses of treatment,the neurological function scores of the treatment and comparison group[(25.63±9.06)points and(57.13±12.03)points]were lower than those before treatment[(64.03±11.41)points and(66.40±13.27)points,all P<0.05].At the end of 2 courses of treatment,the neurological function score of the treatment group was lower than that of the comparison group(P<0.05).The clinical efficacy of the treatment group was more significant(93.3%vs.70.0%,χ^(2)=5.455,P=0.020).At the end of 2 courses of treatment,the 24 h urinary copper values in the treatment and comparison groups[(1690.40±369.90)μg/24 h and(1376.75±311.91)μg/24 h]were higher than those before treatment[(202.33±38.11)μg/24 h and(206.66±38.38)μg/24 h,all P<0.01].The urine copper value in the treatment group was significantly higher than that in the comparison group after treatment(P<0.05).Conclusion Removing blood stasis and resolving phlegm can significantly improve the neurological function of patients with Wilson's disease,the clinical efficacy and the quality of life of patients.
作者
马守亮
杨文明
韩冰
李悦悦
许志豪
宋成玮
韩辉
MA Shou-liang;YANG Wen-ming;HAN Bing;LI Yue-yue;XU Zhi-hao;SONG Cheng-wei;HAN Hui(Encephalopathy Center,the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei,Anhui 230031,China;不详)
出处
《中华全科医学》
2022年第6期910-913,共4页
Chinese Journal of General Practice
基金
国家自然科学基金项目(81973825)
中国民族医药学会科研项目(2020ZY141-410901)
安徽省重点研究和开发计划项目(1804h08020243)。
关键词
祛瘀化痰法
肝豆状核变性
神经功能
Removing stasis and resolving phlegm
Hepatolenticular degeneration
Nerve function
