摘要
目的:探讨丹参红花汤熏洗联合抗血小板药物治疗下肢动脉硬化闭塞症(ASO)疗效及对血清超敏C-反应蛋白(hsCRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)的影响。方法:选择2019年3月至2021年3月南京市浦口区中医院收治的100例ASO患者,按照治疗方式不同分为对照组和实验组,各50例。对照组采用抗血小板药治疗,实验组在对照组基础上加用丹参红花汤熏洗治疗,两组均连续治疗8周。比较两组疗效、中医症状积分、下肢动脉血管功能及血清炎症因子[超敏C反应蛋白(hsCRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平。结果:实验组治疗总有效率明显较对照组优(P<0.05);治疗后两组中医症状积分、足背动脉收缩期峰值流速(PSV)及血清hsCRP、TNF-α及IL-6水平均明显低于同组治疗前(P<0.05),且实验组治疗后均明显较对照组低(P<0.05);两组ABI均明显高于同组治疗前(P<0.05),且实验组治疗后明显较对照组高(P<0.05);两组足背动脉血管内径均明显大于同组治疗前(P<0.05),且实验组治疗后明显较对照组大(P<0.05)。结论:对ASO患者实施丹参红花汤熏洗联合抗血小板药物治疗的效果较佳,可有效降低血清hsCRP、TNF-α、IL-6等炎症因子水平,明显改善下肢动脉血管功能,显著缓解临床症状。
Objective:The objective of this study was to investigate the efficacy of Dan Shen Hong Hua Tang fumigation combined with antiplatelet drugs in the treatment of lower limb atherosclerosis occlusive disease(ASO)and its effects on serum hypersensitive C-reactive protein(hsCRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6).Methods:One hundred patients with ASO admitted to Pukou District Chinese Hospital in Nanjing from March 2019 to March 2021 were selected and divided into a control group and an experimental group,each with 50 cases.The control group was treated with antiplatelet agents,while the experimental group was treated with fumigation with Dan Shen Hong Hua Tang in addition to the control group.Both groups were treated continuously for 8 weeks.The efficacy,TCM symptom score,lower limb arterial vascular function,and serum inflammatory factors(hsCRP,TNF-α,and IL-6)levels were compared between the two groups.Results:The total effective rate of treatment in the experimental group was significantly better than that in the control group(P<0.05).The TCM symptom score,peak systolic flow velocity(PSV)of dorsalis pedis artery,and serum hsCRP,TNF-α,and IL-6 levels were significantly lower in both groups after treatment than before treatment in the same group(P<0.05),and all of them were significantly lower in the experimental group than in the control group after treatment(P<0.05).The ankle-brachial index(ABI)in both groups was significantly higher than before treatment in the same group(P<0.05),and was significantly higher in the experimental group than in the control group after treatment(P<0.05).The internal diameter of the dorsalis pedis artery in both groups was significantly larger than before treatment in the same group(P<0.05),and was significantly larger in the experimental group than in the control group after treatment(P<0.05).Conclusion:The treatment of ASO patients with Dan Shen Hong Hua Tang fumigation combined with antiplatelet drugs was more effective in reducing the levels of serum hsCRP,TN
作者
缪雪梅
曹慧
赵静
MIAO Xuemei;CAO Hui;ZHAO Jing(Department of Laboratory Medicine,Pukou District Hospital of Traditional Chinese Medicine,Nanjing Jiangsu 211800,China)
出处
《四川中医》
2023年第4期71-74,共4页
Journal of Sichuan of Traditional Chinese Medicine
基金
南京市浦口区科技计划项目(编号:2017YS)
关键词
丹参红花汤
抗血小板药物
下肢动脉硬化闭塞症
炎症因子
Danshen Honghua Tang
antiplatelet drugs
lower extremity arteriosclerosis obliterans
inflammatory factors
