摘要
目的探讨补阴益肾汤加减联合雌孕激素序贯疗法治疗卵巢早衰的效果。方法选择2018年1月至2021年1月我院收治的80例卵巢早衰患者为研究对象,按照随机数字表法将其分为对照组与观察组,各40例。对照组给予雌孕激素序贯疗法,观察组在对照组基础上给予补阴益肾汤加减。比较两组的临床疗效、卵巢血流动力学指标[卵巢内动脉血管收缩期峰值流速(PSV)、阻力指数(RI)、加速时间(TA)、加速度(ACC)]、激素[雌二醇(E_(2))、促卵泡生成素(FSH)、抗苗勒管激素(AMH)、黄体生成素(LH)]、抑制素B(INHB)、β-内啡肽(β-EP)水平。结果观察组的治疗总有效率为97.50%,高于对照组的85.00%,差异具有统计学意义(P<0.05)。治疗后,观察组的PSV高于对照组,RI、ACC低于对照组,TA短于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的E_(2)、AMH水平高于对照组,FSH、LH水平低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的INHB、β-EP水平高于对照组,差异具有统计学意义(P<0.05)。结论补阴益肾汤加减联合雌孕激素序贯疗法治疗卵巢早衰的效果显著,可改善卵巢血流动力学指标,调节INHB、β-EP水平。
Objective To explore the effect of modified Buyin Yishen decoction combined with estrogen-progesterone sequential therapy in the treatment of premature ovarian failure.Methods A total of 80 patients with premature ovarian failure treated in our hospital from January 2018 to January 2021 were selected as the research objects.The patients were divided into control group and observation group according to random number table method,with 40 cases in each group.The control group was given estrogen-progesterone sequential therapy,and the observation group was given modified Buyin Yishen decoction on the basis of the control group.The clinical efficacy,ovarian hemodynamic indexes[peak systolic velocity(PSV),resistance index(RI),acceleration time(TA),acceleration(ACC)],hormones[estradiol(E_(2)),follicle-stimulating hormone(FSH),anti-Müllerian hormone(AMH),luteinizing hormone(LH)],inhibin B(INHB),and β-endorphin(β-EP)levels were compared between the two groups.Results The total effective rate of treatment in the observation group was 97.50%,which was higher than 85.00% in the control group,and the difference was statistically significant(P<0.05).After treatment,PSV in the observation group was higher than that in the control group,RI and ACC were lower than those in the control group,TA was shorter than that in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of E_(2) and AMH in the observation group were higher than those in the control group,the levels of FSH and LH were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of INHB and β-EP in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The modified Buyin Yishen decoction combined with estrogen-progesterone sequential therapy in the treatment of premature ovarian failure has a significant effect,it can improve the ovarian hemodynamic indexes and regulat
作者
徐彭丽
XU Pengli(People's Hospital of Tongchuan,Tongchuan 727000,China)
出处
《临床医学研究与实践》
2022年第16期138-141,共4页
Clinical Research and Practice
关键词
补阴益肾汤
雌孕激素序贯疗法
卵巢早衰
Buyin Yishen decoction
estrogen-progesterone sequential therapy
premature ovarian failure
