摘要
目的了解卵巢早衰(prematureovarianfailure,POF)患者的临床特征及治疗现状,以指导临床对POF的诊治。方法回顾性分析2001-08-2004-03北京大学第三医院98例POF患者的临床特征,对98例POF患者和25例正常对照患者的临床数据进行比较,并对POF组中有无家族史者进行临床特征比较。结果21例POF患者有家族史,占21·4%。83例(84·7%)患者阴道超声可探及至少一侧卵巢,20例(20·4%)患者有卵泡样回声,8例有排卵。POF组初潮年龄与对照组无差别,POF组BMI大于对照组(P<0·05)。POF组子宫体积和卵巢体积较对照组明显减小(P<0·01)。POF组抗核抗体阳性率高,但无统计学意义(P>0·05)。家族性POF和散发性POF的临床特征无明显差别。28·6%的患者缺乏规范化的激素替代治疗(hormonereplacementtreatment,HRT)。结论遗传因素和自身免疫因素在POF的发病中占一定地位,但大部分POF为特发性不明原因。POF患者应进行长期的HRT治疗,预防并发症,而赠卵胚胎移植是POF患者获得妊娠的最有效的治疗。
Objective To explore clinical features and current treatment status in Chinese women with premature ovarian failure （POF）. Methods A retrospective study for clinical features was conducted on 98 women with premature ovarian failure from August 2001 to March 2004 in Peking University Third Hospital. Compare the clinical parameters between 98 POF patients and 25 controls with normal ovarian function. Compare the clinical features between the familial and sporadic POF. Results Twenty-one（21.4% ） eases had family history of POF or early menopause （EM）. At least one ovary was visualized in 84. 7% of the POF patients by vaginal ultrasound. The detection of follicular activity was found in 20 （20.4%） patients and ovulation was found in 8 eases. There were no differences in menarehe age in POF patients and controls. The BMI in POF patients was greater than that in controls （ P 〈 0. 05 ）. Mean uterine and ovarian volume was significantly smaller in POF group as compared with the control group （P 〈0. 01 ）. Anti-nuclear antibodies （ANA） were found more frequently in patients with POF than in control patients, but there were no significant differences （ P 〉 0. 05 ）. There were no significant differences in clinical features between familial POF and sporadic POF except more eases of regular menses before menopause in familial POF （90. 5% vs 81.8% ）. 28. 6% POF patients lacked standardized hormone replacement treatment （HRT）. Conclusion Genetic and autoimmune disorders are the main causes of POF, but its eti- ologies remain unknown in most eases. Long-term HRT is needed to prevent long-term health sequel of estrogen deficiency. The only proven therapy for abtalning a pregnancy in POF patients is fertilization of a donor ooeyte.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2007年第1期47-49,共3页
Chinese Journal of Practical Gynecology and Obstetrics
关键词
卵巢早衰
抗核抗体
激素替代治疗
Premature ovarian failure
Anti-nuclear antibodies
Hormone replacement treatment
