摘要
目的探析间歇正压通气(IPPV)+肺表面活性物质(PS)替代疗法治疗新生儿呼吸窘迫综合征(NRDS)的临床效果。方法本研究选取2019年2月—2021年2月郑州市某医院诊治的80例NRDS患儿为研究对象。采用随机数字表法将患儿分为观察组与对照组,每组40例。给予对照组患儿IPPV治疗,观察组患儿在对照组治疗基础上进行PS替代疗法治疗。比较2组患儿治疗2周时的治疗效果;比较2组患儿治疗前及治疗2周时呼吸频率(RR)、潮气量(VT)、达峰时间比、动脉血氧分压(PaO2)、二氧化碳分压(PaCO2)以及血氧饱和度(SaO2)。结果观察组患儿治疗总有效率为95.00%,明显高于对照组的75.00%,差异有统计学意义(P<0.05)。治疗前,2组患儿RR、VT、达峰时间比比较,其差异无统计学意义(P>0.05)。治疗后,2组患儿RR小于治疗前,且观察组小于对照组,差异有统计学意义(P<0.05)。治疗后,2组患儿VT、达峰时间比大于治疗前,且观察组大于对照组,差异均有统计学意义(P<0.05)。治疗前,2组患儿PaO2、PaCO2、SaO2水平比较,差异无统计学意义(P>0.05)。治疗后,2组患儿PaCO2水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,2组患儿PaO2、SaO2水平高于治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05)。结论联合策略(IPPV+PS替代疗法)应用于NRDS患儿治疗中的临床效果显著,可有效改善患儿肺功能及动脉血气指标,值得临床推广。
Objective To observe the clinical effects of IPPV+PS replacement therapy for neonatal respiratory distress syndrome(NRDS).Methods Eighty children with NRDS treated in a hospital in Zhengzhou from Feb-ruary 2019 to February 2021 were selected for this study.The children were divided into observation and control groups using a random number table,40 cases in each group.The children in the control group were given IPPV treatment,and the children in the observation group were treated with PS replacement therapy based on the treat-ment in the control group.The treatment effects of the two groups were compared at 2 weeks of treatment;the respiratory rate(RR),tidal volume(VT),ratio of time to peak tidal expiratory flow to total expiratory time(TPEF/TE),arterial partial pressure of oxygen(PaO2),partial pressure of carbon dioxide(PaCO2)and oxygen saturation(SaO2)of the two groups were compared before and at 2 weeks of treatment.Results The total effec-tive rate of treatment for the children in the observation group was 95.00%,which was higher than that in the control group(75.00%),and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference between the RR,VT and TPEF/TE of children in the 2 groups(P>0.05).After treatment,the RR of children in the 2 groups was smaller than that before treatment and smaller in the ob-servation group than in the control group,with statistically significant differences(P<0.05).After treatment,the VT and TPEF/TE of children in the 2 groups were greater than before treatment and greater in the observa-tion group than in the control group,with statistically significant differences(P<0.05).Before treatment,there was no statistically significant difference in PaO2,PaCO2,and SaO2 levels between the 2 groups of children(P>0.05).After treatment,PaCO2 levels of children in the 2 groups were lower than before treatment and lower in the observation group than in the control group,with statistically significant differences(P<0.05).After treat
作者
杨淑铄
林法涛
陈新亚
Yang Shushuo;Lin Fatao;Chen Xinya(Children's Hospital of Zhengzhou University/Henan Provincial Children's Hospital/Zhengzhou Children's Hospital,Zhengzhou 450000,China)
出处
《保健医学研究与实践》
2022年第4期44-47,共4页
Health Medicine Research and Practice
关键词
新生儿呼吸窘迫综合征
间歇正压通气
肺表面活性物质
肺功能
动脉血气
Neonatal respiratory distress syndrome
Intermittent positive pressure ventilation
Pulmonary surfac-tant
Lung function
Arterial blood gas
