摘要
目的:观察银杏叶提取物注射液联合神经节苷脂治疗缺血性脑血管病患者的效果。方法:选取86例缺血性脑血管病患者为研究对象,按照随机数字表法分为观察组与对照组各43例。两组患者入院后均给予常规治疗,在此基础上对照组予以神经节苷脂治疗,观察组在对照组基础上给予银杏叶提取物注射液治疗,比较两组美国国立卫生研究院卒中量表(NIHSS)评分、颈动脉舒张期末血流速度、脑血管外周阻力、炎性因子[白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤细胞坏死因子-α(TNF-α)]水平和不良反应发生率。结果:治疗后,两组NIHSS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,观察组颈动脉舒张期末血流速度高于对照组,脑血管外周阻力低于对照组,差异均有统计学意义(P<0.05);治疗后,两组IL-6、CRP、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:银杏叶提取物注射液联合神经节苷脂治疗缺血性脑血管病患者可降低NIHSS评分、脑血管外周阻力和炎性因子水平,提高颈动脉舒张期末血流速度,效果优于单纯常规治疗联合神经节苷脂治疗。
Objective:To observe effects of Ginkgo biloba extract injection combined with Ganglioside in treatment of patients with ischemic cerebrovascular disease.Methods:86 patients with ischemic cerebrovascular disease were selected as the research objects and were divided into observation group and control group according to the random number table method,43 cases in each group.Both groups were given routine treatment after admission.On this basis,the control group was given Ganglioside treatment,while the observation group was given Ginkgo biloba extract injection treatment on the basis of that of the control group.The national institutes of health stroke scale(NIHSS)score,the carotid artery enddiastolic blood flow velocity,the peripheral cerebrovascular resistance,the inflammatory factor levels[interleukin-6(IL-6),C-reactive protein(CRP),tumor cell necrosis factor-α(TNF-α)]and the incidence of adverse reactions were compared between the two groups.Results:After the treatment,the NIHSS scores of both groups were lower than those before the treatment;that of the observation group was lower than that of the control group;and the difference was statistically significant(P<0.05).After the treatment,the carotid artery end-diastolic blood flow velocity in the observation group was higher than that in the control group;the peripheral cerebrovascular resistance was lower than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,CRP and TNF-α in the two groups were lower than those before the treatment;those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ginkgo biloba extract injection combined with Ganglioside in the treatment of the patients with ischemic cerebrovascular disease can reduce the NIHSS score,the peripheral cerebrovascular resistance and t
作者
刘春雨
LIU Chunyu(Department of Neurology of People’s Hospital of Xinzheng,Xinzheng 451100 Henan,China)
出处
《中国民康医学》
2022年第6期79-81,共3页
Medical Journal of Chinese People’s Health
关键词
缺血性脑血管病
银杏叶提取物
神经节苷脂
NIHSS评分
脑血管外周阻力
炎性因子
颈动脉
Ischemic cerebrovascular disease
Ginkgo biloba extract
Ganglioside
NIHSS score
Peripheral cerebrovascular resistance
Inflammatory factor
Carotid artery
