摘要
目的 探析缺血性脑血管病患者合并发生脑微出血(cerebral microbleed, CMB)的相关危险性因素以及对抗血小板治疗的影响。方法 选取2018年6月至2020年6月南阳医学高等专科学校第一附属医院收治的缺血性脑血管病患者168例作为观察对象,根据常规的核磁共振检测以及磁敏感加权成像检测SWI将患者分为观察组(合并CMB)92例和对照组(无CMB)76例。对两组患者均应用抗血小板治疗,比较两组患者临床资料、检测结果以及治疗效果,分析CMB发生的相关危险性因素以及CMB对抗血小板治疗的影响。结果 CMB发生的相关危险性因素包括高血压、高胆固醇血症、肥胖、脑卒中病史、脑血管疾病类型、脑白质疏松,差异具有统计学意义(P<0.05)。观察组进行在抗血小板治疗期间脑出血发生的几率(13.04%)显著高于对照组(6.58%),差异有统计学意义(P<0.05)。结论 高血压、高胆固醇血症、肥胖、脑卒中病史、脑血管疾病类型、脑白质疏松为缺血性脑血管病患者合并发生CMB的相关危险性因素。CMB患者在抗血小板治疗期间脑出血几率增加。
Objective To explore the related risk factors of cerebral microbleed(CMB) in patients with ischemic cerebrovascular disease and the influence of antiplatelet therapy. Methods A total of 168 patients with ischemic cerebrovascular disease admitted to our hospital from June 2018 to June 2020 were selected as observation objects. According to conventional MRI and SWI, the patients were divided into observation group(92 cases with CMB) and control group(76 cases without CMB). Patients in the two groups were treated with antiplatelet therapy. Clinical data, test results and treatment effects of the two groups were compared, and the risk factors related to the occurrence of CMB and the influence of CMB antiplatelet therapy were analyzed.Results The related risk factors of CMB included hypertension, hypercholesterolemia, obesity, history of stroke, type of cerebrovascular disease, and white matter osteoporosis, and the differences were statistically significant(P<0.05). The incidence of cerebral hemorrhage in the observation group(13.04%) during antiplatelet therapy was significantly higher than that in the control group(6.58%), and the difference was statistically significant(P<0.05). Conclusion Hypertension, hypercholesterolemia, obesity, history of stroke, type of cerebrovascular disease and white matter osteoporosis are related risk factors for CMB in patients with ischemic cerebrovascular disease. CMB patients have an increased risk of intracerebral hemorrhage during antiplatelet therapy.
作者
周宾
陈士东
刘晓
ZHOU bin;CHEN shi-dong;LIU xiao(Internal Medicine-Neurology,the First Affiliated Hospital of Nanyang Medical College,Nanyang,Henan 473000,China)
出处
《医药论坛杂志》
2022年第3期59-62,共4页
Journal of Medical Forum
关键词
缺血性脑血管病
脑微出血
抗血小板治疗
Ischemic cerebrovascular disease
Cerebral microbleed
Antiplatelet therapy
