摘要
目的探讨银杏叶提取物联合依达拉奉治疗急性脑梗死的疗效及对患者血清超敏C反应蛋白(hs-CRP)水平的影响。方法选择2015年12月至2018年6月期间广州中医药大学附属新会中医院收治的92例急性脑梗死患者为研究对象,根据随机数表法将患者分为观察组和对照组,每组46例,对照组患者给予常规治疗及应用依达拉奉治疗,观察组在此基础上联合应用银杏叶提取物,疗程均为14 d。治疗前后采用美国国立卫生研究院卒中量表(NIHSS)、Barthel指数评估量表(BI)对两组患者进行评分并比较,同时比较两组患者的血清hs-CRP水平和临床疗效。结果治疗后,观察组患者的NIHSS、BI评分分别为(7.91±2.20)分、(64.59±12.65)分,血清hs-CRP水平为(6.72±1.87) mg/L,分别与对照组的(9.43±2.38)分、(57.79±11.42)分、(8.96±2.13) mg/L比较,差异均有统计学意义(P<0.05);观察组患者的治疗总有效率为84.78%,明显高于对照组的67.39%,差异有统计学意义(P<0.05)。结论银杏叶提取物联合依达拉奉注射液治疗急性脑梗死能够抑制炎症反应,促进神经功能的恢复,改善日常生活能力,提高临床疗效。
Objective To investigate the efficacy of Ginkgo biloba extract combined with edaravone in the treatment of acute cerebral infarction and its effect on serum hypersensitive C-reactive protein(hs-CRP) level.Methods Ninety-two patients with acute cerebral infarction treated in Xinhui Hospital of Traditional Chinese Medicine, Guangzhou University of Traditional Chinese Medicine, from December 2015 to June 2018, were selected and randomly divided into two groups according to the random number table, with 46 cases in each group. The control group was treated with routine treatment and edaravone, while the observation group was treated with Ginkgo biloba extract on this basis. The course of treatment was 14 days. Before and after treatment, NIH Stroke Scale(NIHSS) and Barthel Index Scale(BI) were used in the two groups for scoring, and the changes of serum hs-CRP and the clinical efficacy were compared between the two groups. Results After treatment, the NIHSS, BI scores, and serum hs-CRP level of the observation group were 7.91±2.20, 64.59±17.65, and(6.72±1.87) mg/L, respectively, as compared with 9.43±2.38, 57.79±11.42, and(8.96±2.13) mg/L in the control group(P<0.05). The total effective rate of the observation group was 84.78%,significantly higher than 67.39% of the control group(P<0.05). Conclusion Ginkgo biloba extract combined with edaravone injection in the treatment of acute cerebral infarction can inhibit inflammation, promote the recovery of nerve function, and improve daily living ability and clinical efficacy.
作者
张玉松
杨劲松
李洁儿
ZHANG Yu-song;YANG Jin-song;LI Jie-er(Xinhui Hospital of Traditional Chinese Medicine, Guangzhou University of Traditional Chinese Medicine, Jiangmen 529100, Guangdong, CHINA)
出处
《海南医学》
CAS
2019年第12期1507-1509,共3页
Hainan Medical Journal
关键词
急性脑梗死
银杏叶提取物
依达拉奉
炎症因子
疗效
Acute cerebral infarction
Ginkgo biloba extract
Edaravone
Inflammatory factors
Therapeutic effect
