摘要
目的研究阿托伐他汀和葛根素注射液治疗急性脑梗死患者期间对其血清炎症因子的影响。方法选择2013年1～12月我院神经内科收治的128例急性脑梗死患者为研究对象,按照治疗方法分成A组与B组,每组各64例,A组口服阿托伐他汀治疗,B组使用葛根素注射液治疗,比较分析两组患者的临床疗效及血脂、血清炎症因子水平与颈动脉粥样硬化等指标变化。结果 B组的治疗有效率为98.4%,显著优于A组的89.1%,两组比较差异有统计学意义（P〈0.05）。B组治疗后的总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高敏C反应蛋白（hs-CRP）及基质金属蛋白酶-9（MMP-9）水平均较A组降低,高密度脂蛋白胆固醇（HDL-C）水平升高,差异具有统计学意义（P〈0.05）。B组治疗后的颈动脉内膜中层厚度（IMT）与斑块面积均低于A组治疗后差异具有统计学意义（P〈0.05）。结论与阿托伐他汀疗效比较,葛根素注射液治疗效果更确切,抑制血清炎症因子效果更显著,可以明显降低血脂水平及有效逆转颈动脉粥硬化。
Objective To study the effect of Ge Gensu injection（Puerarin） and atorvastatin on serum inflammatory factors in the treatment of acute cerebral infarction. Methods In 2013, 128 patients of acute cerebral infarction were selected. The patients were divided into group A and group B, each with 64 cases. Group A was treated with atorvastatin, and group B used Puerarin injection. The two groups were compared in clinical efficacy, and the changes of blood lipid, carotid atherosclerosis index. Results The effective rate was 98.4% in group B and 89.1% in group A,with statistically significant difference between the two groups（P〈0.05）. After treatment in group B, total cholesterol（TC）, triglyceride（TG）, low-density lipoprotein cholesterol（LDL-C）, high sensitivity C-reactive protein（hs-CRP） and matrix metalloproteinase-9（MMP-9） levels were significantly lower than group A, and the high-density lipoprotein cholesterol（HDL-C） level was significantly increased（P〈0.05）. After treatment in group B, intima-media thickness（IMT） and plaque area were lower than those in group A after treatment（P〈0.05）. Conclusion Compared with atorvastatin, Puerarin injection has better effect, which can suppress serum inflammatory factor more significantly, and decarese blood lipid levels and reversing the carotid atherosclerosis.
出处
《海南医学》
CAS
2015年第6期797-799,共3页
Hainan Medical Journal
关键词
阿托伐他汀
葛根素
脑梗死
炎症因子
血脂
Atorvastatin
Ge Gensu
Cerebral infarction
Inflammatory factor
Blood lipid
