摘要
目的探讨丁苯酞联合双抗血小板治疗进展性脑梗死患者的宏观疗效和微观影响。方法选择浙江省永康市第一人民医院2019年3月-2020年9月收治的94例进展性脑梗死患者,按照随机数表法分为双抗组和联合组,每组47例。双抗组采用双抗血小板治疗,联合组采用丁苯酞联合双抗血小板治疗。比较两组宏观疗效(临床疗效、神经功能、日常生活能力)和微观影响(血管内皮功能、炎性介质)。结果与治疗前比较,两组NIHSS评分、血清ET、TNF-α、CRP、MCP-1水平均明显下降,而Barthel指数、血清NO均明显上升,且联合组上述指标改善情况均优于双抗组,差异有统计学意义(P<0.05);联合组总有效率(93.62%)高于双抗组(76.60%),差异有统计学意义(P<0.05)。结论采用丁苯酞联合双抗血小板治疗进展性脑梗死,可明显提升治疗效果,改善患者神经功能、日常生活能力,有效修复血管内皮损伤,减轻炎症反应。
Objective To investigate the effect of butylphthalide combined with double antiplatelet in the treatment of patients with progressive cerebral infarction and its influence on inflammatory response mediators and neurological function.Methods According to the random number table method,94 patients with progressive cerebral infarction admitted to our hospital from March 2019 to September 2020 were divided into two groups,with 47 cases in each group.The control group was treated with dual antiplatelet therapy,and the study group was treated with butylphthalide combined with dual antiplatelet therapy.The changes in nerve function,daily living ability,vascular endothelial function,and inflammatory response media were compared between the two groups before and after treatment,and the clinical efficacy of the two groups was evaluated.Results Compared with before treatment,the NIHSS score,serum ET,TNF-α,CRP,and MCP-1 levels of the two groups were significantly decreased,while the Barthel index and serum NO were significantly increased.The improvement of the above indicators in the study group was better than that of the control group.The difference was statistically sig-nificant(P<0.05);the total effective rate of the study group(93.62%)was higher than that of the control group(76.60%),and the differ ence was statistically significant(P<0.05).Conclusion The treatment of progressive cerebral infarction with butylphthalide combined with double antiplatelet can significantly improve the treatment effect,improve the patient’s nerve function,daily living ability,repair vascular endothelial injury,reduce inflammation,and promote the patient’s body recovery.It has clinical promotion significance.
作者
黄金华
胡灵芝
HUANG Jinhua;HU Lingzhi(Yongkang First People's Hospital,Yongkang 321300,China)
出处
《浙江实用医学》
2021年第1期10-13,共4页
Zhejiang Practical Medicine
关键词
进展性脑梗死
双抗血小板
丁苯酞
炎症反应
神经功能
日常生活能力
progressive cerebral infarction
double antiplatelet
Butylphthalide
inflammatory reaction
nerve function
ability of daily living
