摘要
目的探究左氧氟沙星联合头孢哌酮舒巴坦治疗老年肺炎的疗效及对患者肺功能和不良反应的影响。方法选取2019年1月至2020年9月本院收治的86例老年肺炎患者,按照随机数字表法分为对照组和观察组,各43例。对照组实施头孢哌酮舒巴坦治疗,观察组实施左氧氟沙星+头孢哌酮舒巴坦治疗,比较两组临床疗效、治疗前后炎症因子和肺功能指标及药物不良反应。结果观察组治疗总有效率为97.67%,高于对照组的86.05%(P<0.05)。治疗前,两组C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)、肿瘤细胞坏死因子-α(TNF-α)水平比较差异无统计学意义;治疗后,观察组CRP、PCT、IL-6、TNF-α水平均低于对照组(P<0.05)。治疗前,两组用力肺活量(FVC)、1 s最大呼气容积(FEV1)、呼气峰值流速(PEF)水平比较差异无统计学意义;治疗后,观察组FVC、FEV1、PEF水平均高于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论采用左氧氟沙星+头孢哌酮舒巴坦治疗老年肺炎患者疗效显著,可明显改善患者炎症反应水平及肺功能指标,且治疗安全性高,值得临床推广应用。
Objective To explore the effect of levofloxacin combined with cefoperazone and sulbactam in the treatment of elderly patients with pneumonia and its influence on lung function and adverse reactions.Methods A total of 86 elderly patients with pneumonia from January 2019 to September 2020 in our hospital were selected and they were divided into control group and observation group according to random number table method,with 43 cases in each group.The control group was treated with cefoperazone and sulbactam,and the observation group was treated with levofloxacin + cefoperazone and sulbactam.The clinical efficacy,inflammatory factors before and after treatment,lung function indicators before and after treatment,and adverse drug reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 97.67%,which was higher than 86.05% in the control group(P<0.05).Before treatment,there was no significant difference in the levels of C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6),and tumor cell necrosis factor-α(TNF-α) between the two groups;after treatment,the levels of CRP,PCT,IL-6 and TNF-α in the observation group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference in the levels of forced vital capacity(FVC),1 s maximum expiratory volume(FEV1),and peak expiratory flow rate(PEF) of the two groups;after treatment,the FVC,FEV1 and PEF levels in the observation group were higher than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups.Conclusion The application of levofloxacin + cefoperazone and sulbactam in the treatment of elderly patients with pneumonia has significant effect,improves the level of inflammation and pulmonary function,and has high treatment safety,which is worthy of clinical application.
作者
张海红
董春景
ZHANG Haihong;DONG Chunjing(Department of Internal Medicine,Dongchangfu District Hospital of Liaocheng City,Liaocheng,Shandong,252000,China)
出处
《当代医学》
2022年第8期80-82,共3页
Contemporary Medicine
关键词
老年肺炎
左氧氟沙星
头孢哌酮舒巴坦
肺功能
Senile pneumonia
Levofloxacin
Cefoperazone and sulbactam
Lung function
