摘要
目的分析甲巯咪唑与丙硫氧嘧啶对甲亢患者甲状腺功能及肝功能指标的影响,为临床用药提供参考。方法选取2020年3月-2021年3月收治的84例甲亢患者,按照随机数字表法分为甲巯咪唑组与丙硫氧嘧啶组,各42例,分别给予甲巯咪唑与丙硫氧嘧啶口服治疗。比较两组甲状腺功能指标[促甲状腺激素(TSH)、三碘甲腺原氨酸(FT3)、四碘甲腺原氨酸(FT4)]、肝功能指标[丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、谷氨酰转肽酶(GGT)]、肝功能受损情况及不良反应。结果两组FT3、FT4低于治疗前,TSH高于治疗前,且甲巯咪唑组FT3、FT4低于丙硫氧嘧啶组,TSH高于丙硫氧嘧啶组,差异有统计学意义(P<0.05);丙硫氧嘧啶组ALT、AST、GGT高于治疗前,且高于甲巯咪唑组,差异有统计学意义(P<0.05);甲巯咪唑组治疗前后ALT、AST、GGT比较,差异无统计学意义(P>0.05);甲巯咪唑组肝损伤率为4.76%,低于丙硫氧嘧啶组的19.05%,差异有统计学意义(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论甲巯咪唑与丙硫氧嘧啶均可有效改善甲亢患者的甲状腺功能,前者效果更佳,且肝损伤毒性更小。
Objective To analyze the effect of methimazole and propylthiouracil on thyroid function and liver function indexes in patients with hyperthyroidism,and to provide reference for clinical medication.Methods A total of 84 patients with hyperthyroidism admitted to our hospital from March 2020 to March 2021 were selected and randomly divided into methimazole group and propylthiouracil group,with 42 cases in each group.The thyroid function indexes[thyroid stimulating hormone(TSH),triiodothyronine(FT3),tetraiodothyronine(FT4)],liver function indexes[alanine aminotransferase(ALT),aspartate aminotransferase(AST),glutamine transferase(GGT)],liver function damage and adverse reactions were compared between the two groups.Results The levels of FT3 and FT4 in the two groups were lower than those before treatment,the level of TSH was higher than that before treatment,the levels of FT3 and FT4 in the methimazole group were lower than those in the propylthiouracil group,the level of TSH was higher than that in the propylthiouracil group,the difference was statistically significant(P<0.05).The levels of ALT,AST and GGT in the propylthiouracil group were higher than those before treatment,and higher than those in the methimazole group,the difference was statistically significant(P<0.05).There was no significant difference in ALT,AST and GGT before and after treatment in methimazole group(P>0.05).The liver injury rate of methimazole group was 4.76%,which was lower than 19.05%of the propylthiouracil group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Both methimazole and propylthiouracil can effectively improve thyroid function in patients with hyperthyroidism.The former has better effect and less liver injury toxicity.
作者
徐晨曦
XU Chen-xi(Department of General Medicine,Tianjin Jizhou District People's Hospital,Tianjin 301900,China)
出处
《医学信息》
2022年第8期147-149,共3页
Journal of Medical Information
关键词
甲亢
甲巯咪唑
丙硫氧嘧啶
甲状腺功能
肝功能
Hyperthyroidism
Methimazole
Propylthiouracil
Thyroid function
Liver function
