摘要
目的观察丙硫氧嘧啶与氟羟强的松龙联合用药在自身免疫性甲状腺(AITD)伴甲亢患者治疗中的临床效果。方法选取2022年1月—2023年3月本院收治的AITD伴甲亢患者104例为研究对象,将其以随机分配方式分成对照组和试验组,每组52例。其中,对照组给予丙硫氧嘧啶治疗,试验组给予丙硫氧嘧啶与氟羟强的松龙联合用药治疗,观察两组治疗效果。结果治疗前,两组TSH、FT3、FT4、TPOAb、TGAb、CT、PTH以及BGP水平对比区别不明显,故无统计学意义(P>0.05);治疗后,TSH、PTH水平两组均有所上升,FT3、FT4、TPOAb、TGAb、CT以及BGP水平则均有所降低,试验组优于对照组,且差异有统计学意义(P<0.05);对照组治疗后的总有效率是78.85%,试验组是96.15%,对比差异有统计学意义(P<0.05)。结论对AITD伴甲亢患者采用药物联合治疗方式效果更为显著,而丙硫氧嘧啶和氟羟强的松龙联合用药疗效优势明显,值得推荐。
Objective To observe clinical effect of combination of propylthiouracil and fluroxypprednisolone in treatment of autoimmune thyroid disease(AITD)with hyperthyroidism.Methods The paper chose 104 AITD patients with hyperthyroidism admitted to our hospital from January 2022 to March 2023 as study subjects,and divided them into control group and experimental group randomly,with 52 cases in each group.Control group was treated with propylthiouracil,while experimental group with combination of propylthiouracil and fluroxydnisolone.Curative effect between two groups was observed.Results Before treatment,there was no significant difference in levels of TSH,FT3,FT4,TPOAb,TGAb,CT,PTH,and BGP between two groups,there was no statistical significance(P>0.05).After treatment,levels of TSH and PTH in both groups increased,while levels of FT3,FT4,TPOAb,TGAb,CT,and BGP decreased.Those in experimental group were higher than control group,with statistical significance(P<0.05).total effective rate after treatment in control group was 78.85%,while that in experimental group was 96.15%,with statistical significance(P<0.05).Conclusion Drug combination therapy can achieve significant effect for AITD patients with hyperthyroidism,while combination of propylthiouracil and fluoromethylprednisolone has significant curative advantage,which is worth recommending.
作者
孙梦欣
SUN Mengxin(Nanjing City Yuhua Hospital,Nanjing,Jiangsu 210000)
出处
《智慧健康》
2024年第1期106-109,共4页
Smart Healthcare
关键词
丙硫氧嘧啶
氟羟强的松龙
自身免疫性甲状腺伴甲亢
Propylthiouracil
Fluorohydroxyprednisolone
Autoimmune thyroid with hyperthyroidism
