摘要
目的分析甲状腺功能亢进疾病特点,观察甲巯咪唑和丙硫氧嘧啶治疗甲状腺功能亢进不良反应的临床效果,为甲状腺功能亢进用药提供参考。方法从2017年11月至2018年11月我院收治的甲状腺功能亢进患者中随机选择120例患者为研究对象,根据治疗药物的不同将其分为两个治疗小组,即治疗A组、治疗B组,每组60例。在其他条件相同的情况下,给予治疗A组甲巯咪唑治疗,给予治疗B组丙硫氧嘧啶治疗。对比两组患者经过不同药物治疗后的效果、不良反应发生情况、血细胞计数异常情况及肝功能受损情况。结果治疗A组的不良反应发生率为15.00%,治疗B组的不良反应发生率为28.33%,两组经过不同药物治疗后的不良反应发生率差异有统计学意义(P<0.05);治疗A组的血细胞计数异常发生率为8.33%,治疗B组为11.67%,P<0.05;治疗A组的肝功能受损发生率为1.67%,治疗B组为6.67%,P<0.05;治疗A组的治疗有效率为91.67%,治疗B组为85.00%,P<0.05。结论临床应用甲巯咪唑和丙硫氧嘧啶治疗甲状腺功能亢进均具有一定的临床效果,但甲巯咪唑治疗的治疗效果更优。
Objective To analyze the characteristics of hyperthyroidism and observe the comparison of clinical effects of adverse reactions in the treatment of hyperthyroidism with methimazole and propylthiouracil,so as to provide reference for the medication of hyperthyroidism.Methods A total of 120 patients with hyperthyroidism admitted to our hospital from November 2017 to November 2018 were randomly selected as the object of this study.According to the different treatment drugs,they were divided into two treatment groups,namely treatment group A and treatment group B,with 60 patients with hyperthyroidism in each group.Other conditions being the same,patients in group A were treated with methimazole and patients in group B were treated with propylthiouracil.The incidence of adverse reactions,abnormal blood cell count,therapeutic effect and impaired liver function were compared between the two groups of patients after different drug treatment.Results The incidence of adverse reactions in patients group A was 15.00%,and that in group B was 28.33%.There was A significant difference in the incidence of adverse reactions between the two groups after different drug treatment(P<0.05).The incidence of abnormal blood count was 8.33%in group A and 11.67%in group B,P<0.05.The incidence of impaired liver function was 1.67%in group A and 6.67%in group B,P<0.05.The effective rate of hyperthyroidism was 91.67%in group A and 85.00%in group B,P<0.05.Conclusion The clinical application of methimazole and propylthiouracil in the treatment of hyperthyroidism has a certain clinical effect,but the treatment effect of methimazole is better.
作者
柳爽
李维筠
LIU Shuang;LI Weijun(the First Hospital of Dandong,Dandong 118000,China)
出处
《中国医药指南》
2022年第23期79-81,共3页
Guide of China Medicine
