摘要
目的探讨抗子宫内膜抗体(AEMAb)、抗心磷脂抗体(ACPAb)、抗绒毛膜促性腺激素抗体(AHCGAb)在女性不孕患者中表达特征及其与生殖激素含量的关联性。方法选取2019年1月至2020年4月唐山市妇幼保健院女性不孕患者89例设为研究组,同期参加常规体检的女性89例设为对照组。统计两组基本资料,并抽取血液样本测定AEMAb、ACPAb、AHCGAb阳性率、生殖激素[垂体泌乳素(PRL)、促黄体生成素(LH)、促卵泡成熟激素(FSH)、雌二醇(E2)]水平,对比研究组不同AEMAb、ACPAb、AHCGAb表达情况患者生殖激素水平。结果盆腔病变、流产或产后并发症、痛经、精神压力、受教育程度、AEMAb、ACPAb、AHCGAb阳性均为女性不孕的独立危险因素(P<0.05);研究组PRL、LH及FSH水平高于对照组,E2水平低于对照组,差异有统计学意义(P<0.05);研究组AEMAb、ACPAb、AHCGAb阳性表达者PRL、LH及FSH水平高于阴性表达者,E2水平低于阴性表达者,差异有统计学意义(P<0.05)。结论不孕患者AEMAb、ACPAb、AHCGAb阳性率显著升高,且与生殖激素水平关系密切,可为临床筛查不孕及治疗提供依据。
Objective To investigate the expression characteristics of anti-endometrial antibody(AEMAb),anti-cardiolipin antibody(ACPAb)and anti-chorionic gonadotropin antibody(AHCGAb)in female infertile patients and their correlation with reproductive hormone levels.Methods A total of 89 female infertile patients in Tangshan Maternal and Child Health Hospital from January 2019 to April 2020 were selected as the research group,and 89 women who participated in routine physical examinations during the same period were selected as the control group.The basic data of the two groups were collected,and blood samples were drawn to determine the positive rate of AEMAb,ACPAb,AHCGAb,reproductive hormones[pituitary prolactin(PRL),luteinizing hormone(LH),follicle-stimulating hormone(FSH),estradiol(E2)]levels.The reproductive hormone levels of patients with different AEMAb,ACPAb,and AHCGAb expression in the study group were compared,and the correlation between female infertility risk factors and reproductive hormone levels and the positive expression of AEMAb,ACPAb,and AHCGAb were analyzed.Results Pelvic lesions,miscarriage or postpartum complications,dysmenorrhea,mental stress,education level,positive AEMAb,ACPAb,and AHCGAb were all independent risk factors for female infertility(P<0.05).The levels of PRL,LH and FSH in the study group were higher than those in the control group,and the level of E2 was lower than that in the control group(P<0.05).The levels of PRL,LH and FSH in the positive expression of AEMAb,ACPAb and AHCGAb in the research group were higher than those in the negative expression,and the E2 level was lower than that in the negative expression(P<0.05).Conclusion The positive rates of AEMAb,ACPAb and AHCGAb in infertile patients were significantly increased,and were closely related to reproductive hormone levels,which could provide a basis for clinical screening and treatment of infertility.
作者
郭婉茹
曾彬
崔静
于婉莹
GUO Wanru;ZENG Bin;CUI Jing;YU Wanying(Prenatal Diagnosis Genetic Disease Diagnosis Center of Tangshan Maternal and Child Health Hospital,Tangshan,Hebei,China,063000;Department of Reproductive Genetics,Tangshan Maternal and Child Health Hospital,Tangshan,Hebei,China,063000)
出处
《分子诊断与治疗杂志》
2022年第3期507-511,共5页
Journal of Molecular Diagnostics and Therapy
基金
河北省医学科学研究课题计划(20210396)。
关键词
抗子宫内膜抗体
抗心磷脂抗体
抗绒毛膜促性腺激素抗体
生殖激素
Anti-endometrial antibody
Anti-cardiolipin antibody
Anti-chorionic gonadotropin antibody
Female
Infertility
Reproductive hormone
