摘要
目的探究治疗前预后营养指数(prognostic nutritional index,PNI)与小细胞肺癌(small cell lung cancer,SCLC)患者预后之间的相关性。方法检索PubMed、Web of Science、Embase、中国知网、万方和维普数据库中探究PNI在SCLC中预后价值的相关文献,检索时间截止到2022年3月9日;主要观察指标为总生存期(overall survival,OS),次要观察指标为无进展生存期(progression-free survival,PFS);利用Stata 12.0软件进行统计分析,合并值为风险比(hazard ratio,HR)和95%置信区间(confidence interval,CI)。结果纳入19项回顾性队列研究,涵盖5999例研究对象。Meta分析结果表明治疗前PNI较低的SCLC患者OS[HR=1.58,95%CI(1.37,1.83),P<0.001]和PFS[HR=1.51,95%CI(1.03,2.22),P=0.037]明显较差。结论治疗前PNI较低或为SCLC患者预后较差的不良因素,可应用到SCLC的预后评估和治疗策略制定方面。
Objective To explore the association of pretreatment prognostic nutritional index(PNI)with the prognosis of small cell lung cancer(SCLC)patients.Methods The PubMed,Web of Science,Embase,China National Knowledge Infrastructure,WanFang and VIP databases were searched for relevant literature which identified the prognostic role of PNI in SCLC up to March 9th,2022.The primary endpoint was overall survival(OS)and the secondary endpoint was progression-free survival(PFS).The hazard ratio(HR)and 95%confidence interval(CI)were combined by Stata 12.0 software.Results A total of 19 retrospective cohort studies were included,involving 5999 participates.The pooled results indicated that low pretreatment PNI predicted poorer OS[HR=1.58,95%CI(1.37,1.83),P<0.001]and PFS[HR=1.51,95%CI(1.03,2.22),P=0.037].Conclusion Low pretreatment PNI may be a risk factor for poor prognosis of SCLC patients and could be applied for the evaluation of prognosis and formulation of therapy strategy.
作者
张立明
宋文鹏
王彦
车国卫
ZHANG Liming;SONG Wenpeng;WANG Yan;CHE Guowei(Department of Thoracic Surgery,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,P.R China;Department of Thoracic Surgery,Sichuan Science City Hospital,Mianyang,Sichuan 621000,P.R China)
出处
《华西医学》
CAS
2022年第3期424-430,共7页
West China Medical Journal
基金
四川省科技计划项目(2020YFS0252)。
关键词
预后营养指数
小细胞肺癌
预后
META分析
Prognostic nutritional index
small cell lung cancer
prognosis
meta-analysis
