摘要
目的：初步探讨预后营养指数（ PNI）评估中晚期非小细胞肺癌（ NSCLC）患者预后的临床应用价值。方法收集经病理确诊的123例中晚期NSCLC患者的临床及实验室资料，计算PNI （ PNI＝血清白蛋白＋5×淋巴细胞计数），分析影响中晚期 NSCLC 患者预后的因素。结果123例NSCLC患者的PNI为46．24±6．56。 PNI与NSCLC患者的年龄、体重减轻和胸腔积液情况均有关（均P＜0．05），与性别、吸烟、咯血、胸痛、呼吸困难、组织学类型、临床分期和化疗情况均无关（均P＞0．05）。全组患者的中位生存时间为19．5个月。高PNI组（ PNI≥46．24）和低PNI组（ PNI＜46．24）患者的中位生存时间分别为25．2个月和16．4个月，1年生存率分别为80．6％和63．9％，2年生存率分别为54．8％和19．6％，差异有统计学意义（ P＜0．001）。单因素分析显示，PNI、年龄、呼吸困难、体重减轻情况均与中晚期NSCLC患者的预后有关（均P＜0．05）。多因素分析显示，PNI为影响中晚期NSCLC患者预后的独立因素（ P＜0．001）。结论 PNI计算简便，是一个较新的评估中晚期NSCLC预后的指标，具有一定的临床应用价值。
Objective To explore the clinical application value of prognostic nutritional index （ PNI） for predicting overall survival（ OS） in patients with advanced non？small cell lung cancer （ NSCLC） . Methods 123 patients with histologically confirmed non？small cell lung cancer were enrolled in this study, and their clinical and laboratory data were reviewed. The PNI was calculated as 10×serum albumin value＋5× total lymphocyte countin peripheral blood. Univariate and multivariate analyses were used to identify the potential prognostic factors for advanced NSCLC. Results PNI of the 123 NSCLC patients was 46.24±6.56. PNI was significantly associated with age, weight loss and pleural effusion （P〈0.05）. However, it showed no relationship with sex, smoking, hemoptysis, chest pain, dyspnea, histological type, clinical stage, and administration of chemotherapy （P〉0.05）.The median OS of the 123 patients was 19.5 months. The median OS in the higher PNI group （PNI≥46.24） and lower PNI group（PNI〈46.24） were 25.2 months and 16.4 months, respectively. The 1？year survival rates were 80. 6% and 63. 9%, and 2？year survival rates were 54.8% and 19.6%,respectively （P〈0.01）.Univariate analysis showed that PNI, age, dyspnea, and weight loss were related to the OS of the advanced NSCLC patients （ P〈0.05） . Multivariate analysis identified PNI as an independent prognostic factor for OS of advanced NSCLC （ P〈0.001） . Conclusion PNI can be easily calculated, and may be used as a relatively new prognostic indicator for advanced NSCLC in clinical practice.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2017年第2期146-149,共4页
Chinese Journal of Oncology
关键词
癌
非小细胞肺
预后营养指数
预后
Carcinoma,non-small-cell lung
Prognostic nutritional index
Prognosis
