摘要
[目的]探讨预后营养指数(prognostic nutritional index,PNI)与小细胞肺癌患者预后的关系。[方法]回顾性分析157例小细胞肺癌患者的临床随访资料。通过对ROC曲线得出PNI的最佳截断值,根据最佳截断值将患者分为PNI高值组及PNI低值组,比较两组的临床病理学特征。采用Cox比例风险模型研究小细胞肺癌患者预后的影响因素。[结果]以PNI值=48.4为最佳截断值时,约登指数为最大值,敏感性为70.6%,特异性为35.8%。PNI低值组中年龄≥60岁、分期为广泛期、乳酸脱氢酶(LDH)升高、未进行放疗者比例较高。多因素生存分析显示:分期、LDH水平、是否放疗、PNI值是小细胞肺癌患者预后的独立影响因素。[结论]PNI值计算简便,可用于协助初步判断小细胞肺癌患者的预后状况。
[Purpose] To investigate the relationship of prognostic nutritional index（PNI） with the prognosis of small-cell lung cancer（SCLC） patients. [Methods] The data of 157 cases with SCLC were analyzed retrospectively. The patients were divided into two groups according to the cutoff value of the PNI：those with a PNI ≥48 and those with a PNI 48. Clinicopathological features were compared between the two groups and potential prognostic factors were analyzed by Cox proportional hazards model. [Results] The optimal cutoff value of the PNI was set at 48.4,with a maximum Youden index,and the sensitivity was 70.6%,the specificity was 35.8%. Patients in the PNI-low group were more likely to be older than 60 years old,extensive disease（ED）,elevated lactate dehydrogenase（LDH）,or without radiotherapy. The multivariate analysis showed that stage,LDH,radiotherapy and PNI value were independent factors in predicting overall survival rate.[Conclusion]The PNI is a simple and useful marker to identify SCLC patients＇ prognosis.
出处
《肿瘤学杂志》
CAS
2015年第7期551-554,共4页
Journal of Chinese Oncology
关键词
预后营养指数
肺肿瘤
癌
小细胞
预后
prognostic nutritional index
lung neoplasms
carcinoma
small cell
prognosis
