摘要
目的探讨患者血清中癌胚抗原(CEA)和神经元特异性烯醇化酶(NSE)含量对小细胞肺癌(SCLC)诊断、疗效监测和预后判断的临床意义。方法用免疫分析法检测SCLC患者、非小细胞肺癌(NSCLC)患者、肺部良性疾病患者和健康体检者的血清CEA和NSE含量,比较各组之间含量的差异,同时比较其对肺癌诊断的敏感性、特异性和诊断符合率。结果 SCLC患者的NSE血清含量明显高于其他组(P<0.01),而SCLC患者的CEA血清含量仅次于NSCLC患者,高于其他组(P<0.01)。SCLC患者的NSE含量与CEA含量比值最大。比较不同肺癌之间的NSE和CEA含量,SCLC患者的NSE血清含量最高,且与CEA含量比值最大(P<0.01)。NSE、CEA单独检测及NSE与CEA联合检测对SCLC诊断结果显示,NSE与CEA联合检测对病情诊断的敏感性最高。结论血清中的NSE和CEA检测均能作为SCLC的诊断指标,而NSE与CEA联合检测的效率最高,有助于SCLC的诊断,可提高肺癌诊断的敏感性、特异性和准确性。
Objective To investigate clinical significance of carcinoembryonic antigen（CEA） in serum and neuron specific enolase（NSE） content in diagnosis,curative effect monitoring and prognosis of small cell lung cancer（SCLC）.Methods Electro chemical luminescence was used to detect the serum CEA and NSE content in patients with SCLC,non-small cell lung cancer（NSCLC） patients,benign lung disease patients and healthy subjects.The content difference comparison between groups,and compared that to lung cancer diagnostic sensitivity,specificity and diagnostic accordance rate at the same time.Results Serum NSE concentration in SCLC patients was significantly higher than other groups（P〈0.01）,CEA serum content of SCLC in patients with only less than NSCLC patients,higher than other groups（P〈0.01）.NSE content and CEA content in SCLC patients with maximum ratio.NSE and CEA content in different lung cancer patients with SCLC,serum NSE content was the highest and with the maximum ratio of CEA content（P〈0.01）.NSE,CEA detection alone,NSE and CEA combined detection of the three Methods showed that,the combined detection of NSE and CEA for the diagnosis of the SCLC with highest sensitivity.Conclusion The serum levels of NSE and CEA can be used as the criteria for the diagnosis of SCLC,and combined detection of NSE and CEA is the highest efficiency,which is useful for the diagnosis of SCLC,can improve its sensitivity,specificity and accuracy.
出处
《检验医学与临床》
CAS
2013年第14期1786-1787,1789,共3页
Laboratory Medicine and Clinic
关键词
小细胞肺癌
癌胚抗原
神经元特异性烯醇化酶
small cell lung cancer
carcinoembryonic antigen
neuron specific enolase
