摘要
探究马铃薯抗性淀粉对高脂血症大鼠的降血糖血脂作用,48只大鼠,按体重随机分成空白对照组和模型对照组,高脂饲料饲喂2周后按总胆固醇(TC)水平随机分为5组:高脂模型组,阳性对照组,马铃薯抗性淀粉高、中、低剂量组。干预6周,测定各组大鼠的体质量、肝脏系数、血脂水平等指标,并观察大鼠肝脏组织病理切片。结果发现,与空白组比较,高脂组体重增加2.21%;心脏、肝脏、肝脏系数、附睾周脂重均有所增加,分别为23.70%、85.84%、63.88%、23.74%;TC、TG、LDL-C及血糖水平升高;高脂模型建立成功。与高脂组比较,实验组体重、肝脏重量、肝脏系数、附睾周脂重降低,降低最大幅度分别为2.50%、14.18%、9.18%、19.46%;TC、TG、LDL-C、AI及血糖水平显著降低,最大幅度分别为29.84%、49.33%、59.21%、43.89%、11.33%,HDL-C无显著差异。HE染色结果显示,与高脂组比较,高、中剂量组大鼠肝脏脂肪变性程度明显改善。表明马铃薯抗性淀粉能降低血糖血脂水平,对高脂血症的预防及治疗具有积极作用。
To explore the hypoglycemic and blood lipid-lowering effects of potato resistant starch on hyperlipidemia rats,48 rats were randomly divided into a blank control group and a model control group according to their body weights.After 2 weeks of high-fat feeding,they were randomly divided into 5 groups according to the total cholesterol(TC)level:high-fat model group,positive control group,and potato resistant starch high-,medium-,and low-dose groups.After 6 weeks of intervention,the body weights,liver coefficients,blood lipid levels and other indicators of the rats in each group were measured,and the pathological tissue sections of their livers were examined.Results:Compared with the blank group,the body weight of the high-fat group increased by 2.21%,the heart weight,liver weight,liver coefficient,and periepididymal fat weight all increased by 23.70%,85.84%,63.88%and 23.74%,respectively;TC,TG,LDL-C and blood sugar levels increased;The high-fat model was successfully established.Compared with the high-fat group,the experimental group's body weight,liver weight,liver coefficient,and periepididymal fat weight decreased,with the largest reductions being 2.50%,14.18%,9.18%,and 19.46%,respectively;The levels of TC,TG,LDL-C,AI and blood sugar were significantly reduced,and the largest reductions were 29.84%,49.33%,59.21%,43.89%and 11.33%,respectively,with no significant difference found in HDL-C.The results of HE staining experiments showed that compared with the high-fat group,the degrees of liver steatosis in the rats of the high-and medium-dose groups were significantly improved.The results showed that potato resistant starch can lower the blood sugar and blood lipid levels,and makes a positive contribution to the prevention and treatment of hyperlipidemia.
作者
尉迟邈
吴建美
高璐
刘登宇
曲琳
YUCHI Miao;WU Jianmei;GAO Lu;LIU Dengyu;QU Lin(Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014000,China;Inner Mongolia Comprehensive Center for Disease Control and Prevention,Hohhot 010000,China;Public Health College,Inner Mongolia Medical University,Hohhot 010000,China)
出处
《现代食品科技》
CAS
北大核心
2022年第3期8-14,共7页
Modern Food Science and Technology
基金
内蒙古自治区自然科学基金项目(2019BS08009)
内蒙古自治区科技计划项目(2021GG0120)。
关键词
马铃薯抗性淀粉
降血糖血脂
高脂血症
potato resistant starch
lowering blood sugar and blood lipids
hyperlipidemia
