摘要
针对高脂饮食引起血脂升高这一广泛性问题,本文研究通过紫山药高抗性淀粉(HRS)干预高脂饮食诱导的高脂血症金黄地鼠,改善其盲肠菌群,实现调节脂质代谢和糖代谢水平。结果表明,高脂饮食诱导后金黄地鼠出现高血脂症状并伴有血糖升高。高剂量HRS(1.5 g/100 g bw)干预4周后,内脏器官和周边脂肪质量显著减小,血液中甘油三酯(TG)、总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)显著降低,高密度脂蛋白胆固醇(HDL-C)显著升高,血糖含量显著降低(P<0.05)。HRS干预后金黄地鼠盲肠中厚壁菌门的数量减少,拟杆菌门和变形菌门的数量增加,代表性优势细菌瘤胃球菌科、毛螺菌科、拟杆菌科S24-7组和梭菌属的丰度增加,有效改善了其盲肠菌群的失衡。
Aiming to solve the widespread problem of hyperlipidemia caused by high-fat diet,this paper studied that the intervention of high-fat diet-induced golden hamsters with hyperlipidemia by high-resistant starch(HRS)prepared from purple yam regulated lipid metabolism and glucose metabolism through improving the caecal microbiota.The results suggested that the golden hamsters showed hyperlipidemia and increased blood glucose by the induction of high-fat diet.After the intervention of 4 weeks of high-dose HRS(1.5 g/100 g bw),the weights of visceral organs and peripheral fats were significantly reduced.Furthermore,triglyceride(TG),total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)in blood,and blood sugar levels were significantly reduced,and high-density lipoprotein cholesterol(HDL-C)was significantly increased(P<0.05).The number of Firmicutes was decreased in the cecum,while the number of Bacteroides and Proteobacteria was increased after HRS intervention.Furthermore,the abundance of representative dominant bacteria groups such as Ruminococcaceae,Lachnospiraceae,Bacteroidales_s24-7_group and Clostridia increased,which effectively improved the imbalance of cecal microbiota.
作者
李涛
宋洪波
安凤平
何洪
黄群
Li Tao;Song Hongbo;An Fengping;He Hong;Huang Qun(College of Food Science,Fujian Agriculture and Forestry University,Fuzhou 350002;Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch,Fuzhou 350002)
出处
《中国食品学报》
EI
CAS
CSCD
北大核心
2021年第3期95-101,共7页
Journal of Chinese Institute Of Food Science and Technology
基金
福建省科技重大专项(2018NZ0003-1)。
关键词
紫山药
抗性淀粉
金黄地鼠
高脂饮食
脂质代谢
盲肠菌群
purple yam
resistant starch
golden hamster
high-fat diet
lipid metabolism
cecal microbiota
