摘要
证候是一个非线性的"内实外虚""动态时空"和"多维界面"的复杂系统,只有采用与证候复杂性相适应的思维方法才能揭示其内涵,而代谢组学的动态性、整体性、系统性等研究特点与中医药学的整体观、辨证论治思维模式相吻合。因此,运用代谢组学方法进行中医证候研究,在辨证分型、证候物质基础、证候代谢途径和证候药效研究等方面有着重要作用。该文综述近年来代谢组学在中医证候研究中的应用,以期推动中医证候的客观化研究。
Syndrome is a nonlinear"internal-excess external-deficiency","dynamic spatial-temporal"and"multi-dimensional"complex system and thus only by using a versatile method can the connotation be expounded.Metabonomics,which is dynamic,holistic,and systematic,is consistent with the overall mode of traditional Chinese medicine(TCM)(holistic view and syndrome differentiation and treatment).Therefore,metabonomics is very important for the research on the differentiation,material basis,and metabolic pathways of syndromes,and efficacy on syndromes.This study reviewed the application of metabonomics in the study of TCM syndromes in recent years,which is expected to objectify the research on TCM syndromes.
作者
吕燕慧
谢磊
陈威
王杰
隗鑫曈
魏艳平
祖先鹏
贺吉香
LYU Yan-hui;XIE Lei;CHEN Wei;WANG Jie;WEI Xin-tong;WEI Yan-ping;ZU Xian-peng;HE Ji-xiang(School of Pharmacy,Shandong University of Traditional Chinese Medicine,Ji'nan 250355,China;School of Pharmacy,Naval Medical University,Shanghai 200433,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2022年第2期367-375,共9页
China Journal of Chinese Materia Medica
基金
国家重点研发计划项目(2019YFC1711000)
国家自然科学基金项目(82004215)
上海市卫生健康委员会卫生行业临床研究专项(20204Y0326)。
关键词
代谢组学
中医证候
辨证分型
证候物质基础
证候代谢途径
metabonomics
traditional Chinese medicine syndrome
syndrome differentiation
syndrome material basis
syndrome metabolic pathway
