摘要
补体C1q/肿瘤坏死因子相关蛋白(CTRPs)是近年来炎症性和代谢性疾病,如冠心病、2型糖尿病、肥胖症等研究领域的热点分子。CTRPs可通过多条信号通路影响炎症激活、血管内皮损伤、脂肪代谢、血糖调控等。而冠心病与血管炎症相关,且患者常伴发代谢性疾病。因此,本文就CTRPs在冠心病中作用的研究进展作一综述,以期为冠心病的预防、诊断和治疗提供新靶点。
Complement C1 q/tumor necrosis factor-related proteins(CTRPs)is a hot molecule in recent research fields on inflammatory and metabolic diseases such as coronary heart disease,type 2 diabetes,and obesity.CTRPs have impacts on inflammation activation,vascular endothelial injury,fat metabolism,and blood glucose regulation through multiple signaling pathways.Coronary heart disease is related to vascular inflammation,and mostly accompanied by metabolic diseases.This paper reviews the research progress of CTRPs in coronary heart disease,so to provide new targets for the prevention,diagnosis,and treatment of coronary heart disease.
作者
于高修
陈峰
YU Gao-xiu;CHEN Feng(Graduate School of Naval Medical University,Shanghai 200433,China;Department of Cardiology,Changhai Hospital,Naval Medical University,Shanghai 200433,China)
出处
《中国临床医学》
2022年第1期105-110,共6页
Chinese Journal of Clinical Medicine
基金
海军军医大学长海医院科主任科研基金(20BJZ11)。
关键词
补体C1q/肿瘤坏死因子相关蛋白
冠心病
炎症
代谢性疾病
complement C1q/tumor necrosis factor-related protein
coronary heart disease
inflammation
metabolic disease
