摘要
目的探讨血清中补体C1q/C3比值与冠心病(CHD)发病的关系。方法选取2018年12月―2019年3月在我院住院并经冠状动脉造影检查确诊为CHD的患者67例(CHD组),依据Gensini评分将CHD组分为冠状动脉轻度狭窄组(B组)36例,冠状动脉重度狭窄组(C组)31例;同期因胸痛、胸闷及憋气等症状住院但经冠状动脉造影及其他检查排除CHD者34例为对照组(A组),检测各组血清中C1q、C3水平,计算C1q/C3比值,并分析C1q/C3比值与CHD发病的关系。结果CHD组血清中C1q水平及C1q/C3比值与A组相比明显降低,差异有显著性(t=2.365、3.281,P<0.05);C组C1q/C3比值较A组显著降低,差异有显著性(F=8.055,P<0.05)。经二分类Logistic回归分析结果显示,C1q/C3比值与CHD发病密切相关(95%CI=0.947~0.994,P<0.05)。结论CHD患者血清中C1q/C3比值显著降低,可能是CHD发病的保护性因素,对动脉粥样硬化严重程度有潜在的预测价值。
Objective To investigate the association between serum C1 q/C3 ratio and coronary heart disease(CHD). Methods A total of 67 patients who were hospitalized in our hospital from December 2018 to March 2019 and were diagnosed with CHD by coronary angiography were enrolled as CHD group, and according to the Gensini score, they were divided into mild coronary artery stenosis group(group B with 36 patients) and severe coronary artery stenosis group(group C with 31 patients). Ano-ther 34 patients who were hospitalized due to chest pain, chest distress, and suffocation during the same period of time and did not have CHD were enrolled as control group(group A). Serum levels of C1 q and C3 were measured, C1 q/C3 ratio was calculated, and the association between C1 q/C3 ratio and CHD was analyzed. Results Compared with group A, the CHD group had significant reductions in serum C1 q and C1 q/C3 ratio(t=2.365,3.281,P<0.05), and group C also had a significant reduction in C1 q/C3 ratio(F=8.055,P<0.05). The binary logistic regression analysis showed that C1 q/C3 ratio was closely associated with CHD(95%CI=0.947-0.994,P<0.05). Conclusion There is a significant reduction in C1 q/C3 ratio in patients with CHD, which may be a protective factor against CHD and has a potential value in predicting the severity of atherosclerosis.
作者
刘睿泽
刘松
LIU Ruize;LIU Song(Department of Cardiology,The Affiliated Hospital of Qingdao University,Qingdao 266003,China)
出处
《精准医学杂志》
2020年第1期65-68,共4页
Journal of Precision Medicine
