摘要
目的:观察自拟柴黄利胆方对慢性胆囊炎肝胆湿热证患者的治疗效果,探讨其对炎性因子水平及免疫球蛋白变化的影响。方法:选取肝胆湿热型慢性胆囊炎患者108例,随机分为观察组和对照组各54例。对照组给予西医常规治疗,观察组在对照组基础上加用自拟柴黄利胆方。治疗4周后,对比2组患者临床疗效,中医证候评分评价患者中医相关症状改善情况,超声检测患者胆囊壁厚度和胆囊收缩率变化,全自动生化分析仪检测患者外周血中谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBiL)、总胆汁酸(TBA)生化指标变化,ELISA检测白细胞介素(IL-6)、肿瘤坏死因子(TNF-α)、超敏C反应蛋白(hs-CRP)炎性因子水平变化,免疫散射比浊法检测免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平变化。结果:2组患者治疗前各项指标比较,差异无统计学意义(P>0.05),经治疗4周后,观察组临床有效率明显高于对照组,中医证候评分较对照组显著降低,胆囊壁厚度显著低于对照组,胆囊收缩率较对照组明显升高,血清中ALT、AST、TBiL、TBA生化指标、IL-6、TNF-α、hs-CRP炎性因子及IgA、IgG、IgM水平较对照组均明显降低(均P<0.05)。结论:自拟柴黄利胆方对肝胆湿热型慢性胆囊炎具有较好的临床疗效,可缓解患者临床症状,改善肝功能,其作用机制可能与下调炎性因子和免疫球蛋白的水平相关。
Objective:To observe the therapeutic effect of Chaihuang Lidan Decoction on patients with liver and gallbladder damp heat syndrome of chronic cholecystitis,and to explore its effect on the level of inflammatory factors and the changes of immunoglobulin.Methods:One hundred and eight patients with chronic cholecystitis of liver and gallbladder damp heat type were randomly divided into study group and control group.The control group was given routine treatment of western medicine,and the observation group was added with self-made Chaihuang Lidan Decoction on the basis of the control group.After 4 weeks of treatment,compare the clinical efficacy of the two groups,evaluate the improvement of TCM related symptoms by TCM syndrome score,the changes of gallbladder wall thickness and gallbladder contraction rate were detected by ultrasonography,the changes of biochemical indexes of alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBiL)and total bile acid(TBA)in patients’peripheral blood were measured by automatic biochemical analyzer.The levels of interleukin-6(IL-6),tumor necrosis factor(TNF-α)and high-sensitivity C-reactive protein(hs-CRP)were measured by ELISA,and the levels of immunoglobulin A(IGA),immunoglobulin G(IgG)and immunoglobulin M(IgM)were detected by immune scattering turbidimetry.Results:There was no significant difference in various indexes between the two groups before treatment(P>0.05).After 4 weeks of treatment,the clinical effective rate of the observation group was significantly higher than that of the control group,the TCM syndrome score was significantly lower than that of the control group(P<0.05),the levels of the biochemical indexes ALT,AST,TBiL,TBA,and inflammatory factors IL-6,TNF-α,hs-CRP and IgA,IgG,IgM in serum were significantly lower than those in the control group(P<0.05).Conclusion:Chaihuang Lidan Decoction has a good clinical effect on chronic cholecystitis of liver and gallbladder damp heat type.It can alleviate the clinical symptoms and improve liver fu
作者
曹鹏飞
杨威涛
周雯
杨娇
杨泽江
CAO Pengfei;YANG Weitao;ZHOU Wen;YANG Jiao;YANG Zejiang(Department of Spleen and Stomach Diseases,Hebei Yiling Hospital,Shijiazhuang,050000,China;The First Department of Internal Medicine,Chengde Hospital of Traditional Chinese Medicine)
出处
《中国中西医结合消化杂志》
CAS
2022年第1期11-15,共5页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
河北省中医药管理局科研计划项目(No:2021195)。
关键词
慢性胆囊炎
肝胆湿热证
自拟柴黄利胆方
炎性因子
免疫球蛋白
chronic cholecystitis
liver and gallbladder damp heat syndrome
Chaihuang Lidan Decoction
inflammatory factors
immunoglobulin
