摘要
目的探究消炎利胆胶囊结合西医常规治疗对慢性胆囊炎患者β内啡肽(β-EP)和肿瘤坏死因子-α(TNF-α)的影响。方法将128例慢性胆囊炎患者随机分为治疗组(64例)和对照组(64例)。对照组采用西医常规治疗,治疗组在对照组基础上采用消炎利胆胶囊。比较两组患者的肝胆功能、疗效、症状积分、TNF-α、β-EP及超氧化物歧化酶(SOD)水平。结果治疗后的治疗组总有效率为93.75%(60/64),显著高于对照组(79.69%,51/64),差异具有统计学意义(P<0.05)。治疗后,两组患者TNF-α、β-EP、谷丙转氨酶(ALT)、谷草转氨酶(AST)及总胆红素(TBIL)水平均降低(P<0.05),且治疗组TNF-α、β-EP、ALT、AST及TBIL水平低于对照组(P<0.05)。治疗后两组患者SOD水平均升高(P<0.05),且SOD水平高于对照组(P<0.05)。治疗后,两组患者右上腹隐痛积分,腹胀积分以及恶心、呕吐积分均降低,且治疗组上述3个积分低于对照组(P<0.05)。结论在西医常规治疗的基础上加用消炎利胆胶囊,对慢性胆囊炎的治疗效果较好,患者TNF-α及β-EP因子水平下降,抑制炎性反应及氧化应激,肝胆损伤及临床症状均得到改善,值得临床推广使用。
Objective To explore the effect onβendorphin(β-EP)and tumor necrosis factor-α(TNF-α)in patients with chronic cholecystitis using Xiaoyan Lidan Capsule(消炎利胆胶囊)combined with routine western medicine.Methods 128 patients with chronic cholecystitis were randomly divided into the observation group(n=64)and the control group(n=64).The control group was treated with routine western medicine,and the observation group was treated with Xiaoyan Lidan Capsule on the basis of the control group.The hepatobiliary function,curative effect,symptom score,TNF-α,β-EP and superoxide dismutase(SOD)were compared between the two groups.Results The total effective rate in the observation group was 93.75%(60/64),which was significantly higher than that in the control group(79.69%,51/64)(P<0.05).After treatment,the levels of TNF-α,β-EP,alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TBIL)in the two groups all decreased(P<0.05),and the levels of TNF-α,β-EP,ALT,ALT,AST and TBIL in the observation groupwere lower than those in the control group(P<0.05).After treatment,the level of SOD was increased in both groups(P<0.05),and the level of SOD was higher than that in control group(P<0.05).After treatment,the scores of right epigastric pain,abdominal distension,nausea and vomiting in the two groups decreased,and the above in the observation group were lower than those in the control group(P<0.05).Conclusion The treatment of chronic cholecystitis with Xiaoyan Lidan Capsule on the basis of routine treatment of western medicine is effectivereduce the levels of TNF-αandβ-EP,suppress inflammatory reaction and oxidative stressliver and gallbladder injury and clinical symptoms are improvedis worthy for clinical application.
作者
翟晓刚
马荣炜
范松
刘彩霞
ZHAI Xiaogang;MA Rongwei;FAN Song;LIU Caixia(Department of Gastroenterology,Hebei Armed Police Corps Hospital,Shijiazhuang 050081,Hebei,China)
出处
《辽宁中医杂志》
CAS
2021年第11期135-138,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
河北省科学技术研究与发展计划项目(SZ20184652)
关键词
消炎利胆胶囊
慢性胆囊炎
Β内啡肽
肿瘤坏死因子-α
肝胆功能
症状积分
Xiaoyan Lidan Capsule(消炎利胆胶囊)
chronic cholecystitis
βendorphin
tumor necrosis factor-α
hepatobiliary function
symptom score
